Glomerular hypertrophy is associated with hyperinsulinemia and precedes overt diabetes in
aging rhesus monkeys
Not exact matches
Golub administered epidural bupivacaine to pregnant
rhesus monkeys at term, and followed the development of the exposed offspring to
age 12 months (equivalent to four years in human offspring).
At a Society of Toxicology meeting last week in Reston, Virginia, three groups presented data showing that
rhesus monkeys fed severely calorie - restricted diets show fewer signs of diseases associated with advancing
age, including diabetes, heart disease, and cancer, than their comfortably full — and in some cases comparably lean — counterparts.
The verdict, from a 25 - year study in
rhesus monkeys fed 30 % less than control animals, represents another setback for the notion that a simple, diet - triggered switch can slow
ageing.
Canto and Owen were among the subjects in a pioneering long - term study of the links between diet and
aging in
rhesus macaque monkeys.
And research in
rhesus monkeys suggests similar benefits in primates: One study found that monkeys eating 30 percent less than their cage mates appeared to be protected from
age - related diseases and had lower mortality 15 to 20 years later.
In September a 25 - year study conducted by the National Institute on
Aging, in Baltimore, found that
rhesus monkeys fed a moderate diet lived just as long as those receiving 25 to 30 percent fewer calories.
After 20 long years of waiting, scientists have concluded that
rhesus monkeys that eat nearly a third less food than normal monkeys
age more slowly.
In the PLOS ONE paper, Chan and colleagues describe how three male
rhesus macaques they studied displayed cognitive and motor impairments emerging at 16 months of
age, and dystonia and signs of neurodegeneration on brain imaging at 24 months of
age.
Infant weight growth and weaning
age in freeranging
rhesus macaques (Macaca mulatta).
Age - related decreases in SYN levels associated with increases in MAP - 2, apoE, and GFAP levels in the
rhesus macaque prefrontal cortex and hippocampus.
Brain
aging in humans, chimpanzees (Pan troglodytes), and
rhesus macaques (Macaca mulatta): magnetic resonance imaging studies of macro - and microstructural changes.
Ten male Indian
rhesus macaques (Macaca mulatta),
aged 2 — 3 years were subjected to infection with B. burgdorferi by nymphal Ixodes scapularis tick feeding.
CR can lower the prevalence of
age - related loss of function and multiple diseases, including tumors, cardiovascular disease, neurodegeneration, and protects against diabetes, cancer, cardiovascular disease, sarcopenia, and neurodegeneration of certain brain regions in
rhesus monkeys (31).
The impact of the full program (prenatal and infancy home visitation) on children's use of alcohol and number of sexual partners is important because recent evidence indicates that alcohol use prior to
age 15 years multiplies the risk of alcoholism in adulthood26 and multiple partners increase the risk for sexually transmitted diseases, including human immunodeficiency virus infection.27, 28 The effect of the program on alcohol use is consistent with greater alcohol consumption observed among adult
rhesus monkeys who experienced aberrant rearing.29 These findings must be tempered, however, with an acknowledgment of their limitations.