Sentences with word «agonist»

Biophysical properties and responses to glutamate receptor agonists of identified subpopulations of rat geniculate ganglion neurons

In contrast, the second angiopoietin ligand, Ang2 acts as partial agonist of Tie2, that is, it inhibits Tie2 signalling in the presence of Ang1 and weakly activates Tie2 in the absence of Ang1 (ref.

In 2005 a Mayo Clinic study found 11 cases of patients who had developed gambling habits while taking dopamine agonists for Parkinson's disease.

Two such partial agonists with clinical potential are D - cycloserine and GLYX - 13 [75,76].

Q: I've been taking dopamine agonists for my RLS for a few months now, but I'm starting to feel my symptoms coming back.

Dr. Shapiro's innovations also include the combination of GnRH agonist with low - dose hCG to realize the benefits of each trigger agent.

These chemicals work as agonists of insect nicotinic acetylcholine receptors, but their effect on mammals has been unclear.

«Rare genetic variations may account for life - threatening reaction to long - acting beta agonist drugs in some people.»

These results suggest GSK2636771 treatment can «synergize» with OX40 agonist antibodies to augment effector functions of tumor - reactive T cells.»

α - Adrenergic agonists such as phenylpropanolamine (PPA), ephedrine, pseudoephedrine, and phenylephrine act directly on smooth muscle receptors to increase urethral tone and maximal urethral closure pressure.

«These results also provide a rationale to explore the clinical activity of an OX40 agonist antibody in combination with GSK2636771 in cancer patients with PTEN loss tumors.»

Neonatal abstinence syndrome is a drug withdrawal syndrome that may result from chronic maternal opioid use during pregnancy and is an expected and treatable condition seen in 30 — 80 % of infants born to women taking opioid agonist therapies (43, 85).

Protective effect of Growth Hormone - Releasing Hormone agonist in bacterial toxininduced pulmonary barrier dysfunction.

The main neural adaptation underpinning the velocity - specificity effect is probably an increase in early phase agonist activation.

Dr. Shapiro was among the first in the world to standardize the use of GnRH agonist triggers in high responders undergoing ovarian stimulation, a practice that virtually eliminates ovarian hyperstimulation syndrome (OHSS).

CB2 cannabinoid agonists such as WIN55,212 - 2 inhibit experimental autoimmune encephalomyelitis (EAE), an animal model of MS, by mediating apoptosis of the encephalitogenic cells that induce brain inflammation (41).

Chronic exposure to melatonin receptor agonists does not alter their effects on suprachiasmatic nucleus neurons.

We report the crystal structure of a human β2 - adrenergic receptor — T4 lysozyme fusion protein bound to the partial inverse agonist carazolol at 2.4 angstrom resolution.

Mirabegron is a so called beta 3 - adrenoceptor agonist, which activates the corresponding receptors in the muscle cells of the urinary bladder causing the smooth muscles to also relax.

Effects of dopamine D1 and D2 receptor agonists on environmental enrichment attenuated sucrose cue reactivity in rats

Since then, other TPO agonists have been developed without this problem.

Schubert U, Schmid J, Lehmann S, Zhang XY, Morawietz H, Block NL, Kanczkowski W, Schally AV, Bornstein SR, Ludwig B. Transplantation of pancreatic islets to adrenal gland is promoted by agonists of growth - hormone - releasing hormone.

PPAR gamma agonists also showed efficacy in multiple models of neurodegenerative diseases, meaning that MIN - 102 also offers a significant potential for indication expansion.

Reversing vascular dysfunction in rheumatoid arthritis: improved augmentation index but not endothelial function with peroxisome proliferator - activated receptor γ agonist therapy.

BPA is believed to exert its biological effects largely through loose occupancy of the estrogen receptor, and there are reports of both estrogen agonist [7] and androgen antagonist [8] activity.

Generally, opiate detox involves the use of Buprenorphine, an opiate agonist medication which attaches to the opiate receptors in the brain, blocking the opiates of abuse from affecting the addict.

The CB2 agonist also doesn't appear to be addictive; rats who had received it didn't seek out another infusion unless they were in pain.

Consequently pharmaceutical companies have produced GABA agonists such as acamprosate to prescribe to people suffering form alcohol addition.

Peroxisome proliferator - activated receptor γ agonist effect on rheumatoid arthritis: a randomized controlled trial.

In the National Institutes of Health - funded study, researchers at Wake Forest Baptist identified and evaluated six rare gene variants within the beta2 - adrenergic receptor gene, the gene that may influence the response to beta agonist drugs.

Bohn said the new findings clearly demonstrate that the strategy of developing biased KOR agonists offers a promising new way to treat pain and intractable itch without the potential for abuse.

Discovery of a ligand that compensates for decreased endogenous agonist potency of melanocortin - 4 receptor polymorphisms identified in obese humans.

SARMs act as full agonists at the androgen receptor within the body.

for article Development of a selective agonist for relaxin family peptide receptor 3.

Mouse fibroblasts transformed with this clone bind serotonin agonists and antagonists and exhibit an increase in intracellular Ca2 + concentrations in response to serotonin.

Due to the serious side effects caused by the activation of the pharmacologically and structurally closely related subtypes, it is essential that 5 - HT2C agonists developed for clinical use have a high specificity and subtype selectivity.

Study 2 was a double - blind, randomized, placebo - controlled, parallel group, 18 - week study, investigating AZILECT 1 mg as adjunct therapy to dopamine agonists without levodopa.

In cold tumors, iTeos is pioneering a truly original approach with the targeted tumor delivery of STING agonists using nanoparticle delivery, in collaboration with Cristal Therapeutics.

Butorphanol tartrate, also known as Torbutrol ® is an opiate agonist used by veterinarians primarily as an anti-tussive, to help alleviate coughing.

Be sure to take 90 - 120 seconds between agonist supersets to recover.

However, in recent years, studies have identified a relationship between agonist muscle size and the size of the internal moment lengths (Sugisaki et al. 2010; Akagi et al. 2012).

When you use this type of superset, you do not get the same degree of stress to a single muscle group as you would with agonist sets — which is a primary goal of super setting.

In 2005 the FDA approved Requip, a dopamine agonist used to treat Parkinson's disease, for the treatment of moderate to severe RLS.