The main neural adaptation underpinning the velocity - specificity effect is probably an increase in early phase
agonist activation.
Such differences might be reflected in differences in
agonist activation (measured by electromyography) and voluntary activation, and the sources of the differences could occur at either the spinal or cortical levels.
Like
agonist activation, antagonist co-activation is generally measured using EMG amplitudes.
Not exact matches
Partial
activation of the yeast pheromone response pathway by beta - adrenergic receptor
agonists was achieved in cells coexpressing h beta - AR and a mammalian G protein (Gs) alpha subunit - demonstrating that these components can couple to each other and to downstream effectors when expressed in yeast.
These cells were shown to respond in vivo to
agonists of the TLR family, and this response was dependent on
activation of DCs and on IL - 12 derived from the activated DCs signaling the Vα14 iNKT cells.
Yachi, P.P., Lotz, C., Ampudia, J. & Gascoigne, N.R.J. T cell
activation enhancement by endogenous pMHC acts for both weak and strong
agonists but varies with differentiation state.
The lab's findings in the study, «D - serine Deficiency Attenuates the Behavioral and Cellular Effects Induced by the Hallucinogenic 5 - HT2A Receptor
Agonist DOI,» suggested that D - serine - dependent NMDAR activity is involved in mediating the cellular and behavioral effects of 5 - HT2AR
activation.
Ang2 has been shown to act as partial
agonist of Tie2, that is, it is an antagonist of Tie2
activation in the presence of Ang1 and a weak
agonist in the absence of Ang1 (ref.
Reconstructing and deconstructing
agonist - induced
activation of integrin αIIbβ3.
Mechanism of AMPA Receptor
Activation by Partial
Agonists.
Due to the serious side effects caused by the
activation of the pharmacologically and structurally closely related subtypes, it is essential that 5 - HT2C
agonists developed for clinical use have a high specificity and subtype selectivity.
He will now investigate a set of molecules called TLR
agonists that act through receptors on the surfaces of innate immune cells to set off a chain reaction of molecular signaling and
activation within the immune system, which includes
activation of latently infected CD4 cells.
It's also effective to alternate
agonist / antagonist exercises to increase motor unit
activation, as long as you allow for enough rest in - between sets.
In addition to increased early phase neural drive of the
agonist muscles, velocity - specific strength is likely achieved through a decrease in antagonist muscle
activation (Pousson et al. 1999) and an increase in coordination (Almåsbakk & Hoff, 1996).
EMG amplitudes are often used to measure
agonist muscle
activation in order to:
EMG amplitudes are also used to draw inferences about
agonist muscle
activation.
compare the changes in the
agonist muscle
activation of a prime mover muscle as a result of a long - term strength training program.
Indeed, this is underscore by the fact that some carefully controlled studies have reported that substantial early phase strength gains occur in as little as 5 days without changes in
agonist muscle
activation as measured by EMG amplitudes (Holtermann et al. 2005).
Using the strict definition, voluntary
activation refers to the percentage of involuntary force production that can be exerted by an
agonist muscle group, most commonly using the interpolated twitch technique (Shield & Zhou, 2004).
Even though there are substantial problems with using EMG amplitudes to measure changes in
agonist muscle
activation over time, it is not uncommon for researchers to use it in this way.
This very important study is one of the very few that have actually tested the idea, by assessing the effects of just 5 days of training in untrained subjects on strength gains and on
agonist, synergist, and antagonist
activation levels.
In addition to increased early phase neural drive of the
agonist muscles, it is possible that a greater suppression of antagonist muscle
activation could contribute to increased velocity - specific strength (Pousson et al. 1999).