Sentences with phrase «agonist antibodies»

Many studies in tumor models have forcibly provided 4 - 1BB signals, injecting either agonist antibodies to 4 - 1BB, or transfecting 4 - 1BBL into the tumor cells, also highlighting the stimulatory capability of 4 - 1BB in driving suppression of tumor growth largely through augmenting CTL and NK responses.

These results suggest GSK2636771 treatment can «synergize» with OX40 agonist antibodies to augment effector functions of tumor - reactive T cells.»

To confirm this synergistic effect, the team measured serum levels of signaling proteins in tumor - bearing mice receiving OX40 agonist antibodies alone or in combination with GSK2636771.

«These results also provide a rationale to explore the clinical activity of an OX40 agonist antibody in combination with GSK2636771 in cancer patients with PTEN loss tumors.»

«In our latest study, results suggest that the combination of an OX40 agonist antibody and GSK2636771 may induce robust and durable antitumor T - cell immunity,» said Weiyi Peng, M.D., Ph.D., assistant professor of Melanoma Medical Oncology, and co-lead of the study.

Not exact matches

Announced a clinical trial collaboration with Pfizer, Inc. (Pfizer) to evaluate the safety and efficacy of the investigational combination of Yescarta and Pfizer's utomilumab, a fully humanized 4 - 1BB agonist monoclonal antibody, in patients with refractory large B - cell lymphoma.

Results from a preclinical study conducted in collaboration with researchers at Beth Israel Deaconess Medical Center evaluating the combination of a proprietary investigational oral toll - like receptor 7 agonist, GS - 9620, and a proprietary investigational broadly neutralizing antibody, as part of an HIV eradication strategy.

«The results are relevant for clinical use of specific antibodies or related inhibitors in IL - 17RA dependent severe asthma, suggesting equal efficacy using either agonist or receptor blockade to treat severe asthma crisis,» said Ryffel.

The researchers demonstrated the method by using it to find a potent antibody mimic, or «agonist,» of erythropoietin (EPO), a hormone that stimulates the production of red blood cells.

One such antibody agonist, which can turn stem - like cells in bone marrow into young brain cells, was described in a report in the Proceedings of the National Academy of Sciences last month.

The mouse TPO receptor is almost identical to human TPO receptor, so Zhang was able to test his antibody agonist in mice.

In addition to a range of antibodies, Abcam offers over 4,000 pharmacological tools covering receptor agonists and antagonists, like Tamoxifen Citrate and oestrogen receptor, which is also used in the control of gene expression.

As part of the webinar series, Abcam would like to offer you a 50 % discount on the following product ranges: neuronal marker antibodies, Alexa Fluor ® conjugated secondary antibodies, agonists and antagonists, ion channel blockers and enzyme inhibitors and modulators.

For LTßR agonist treatment, mice were treated with agonistic anti-LTβR antibody (3C8, provided by Carl F Ware) by i.p. injection of 100 μg of antibody every 3 days for 6 days.