Sentences with phrase «agonist of»

The LJPC - 501 is a peptide agonist of the renin - angiotensin system, which is designed to help restore kidney function in patients with hepatorenal syndrome.

Ibutamoren is an active agonist of the growth hormone secretagogue receptor (GHS - R1a).

As an agonist of the GLP - 1 receptor, Exendin - 4 is a potent stimulator of insulin secretion and has a much longer half life than GLP - 1 (~ 2 minutes) making it a suitable drug candidate for the treatment of obesity and type - 2 diabetes.

administering to the subject an effective amount of a compound that stimulates bone formation and inhibits bone resorption, wherein said compound is an agonist of a cannabinoid receptor and wherein said subject having a bone disease or condition is a subject having a disease or condition selected from the group consisting of periodontal disease or defect, osteolytic bone disease other than osteoporosis, post-plastic surgery, post-orthopedic implantation, post-dental implantation, age - related osteoporosis, osteoporosis associated with post-menopausal hormone status, primary and secondary hyperparathyroidism, disuse osteoporosis, diabetes - related osteoporosis, osteoporosis associated with depression, osteoporosis associated with hypogonadism and glucocorticoid - related osteoporosis.

Ang2 is a partial agonist of Tie2 that acts as functional antagonist of Ang1 in Tie2 expressing cells8, 10.

Furthermore, the drug was characterized as agonist of casein kinases 1 (CK1); however, this effect was not confirmed and in colon cancer cells there was no correlation between PPAM toxicity and mutations in Wnt signaling mediators [57, 58].

Ang2 has been shown to act as partial agonist of Tie2, that is, it is an antagonist of Tie2 activation in the presence of Ang1 and a weak agonist in the absence of Ang1 (ref.

In contrast, the second angiopoietin ligand, Ang2 acts as partial agonist of Tie2, that is, it inhibits Tie2 signalling in the presence of Ang1 and weakly activates Tie2 in the absence of Ang1 (ref.

These chemicals work as agonists of insect nicotinic acetylcholine receptors, but their effect on mammals has been unclear.

Biophysical properties and responses to glutamate receptor agonists of identified subpopulations of rat geniculate ganglion neurons

These cells were shown to respond in vivo to agonists of the TLR family, and this response was dependent on activation of DCs and on IL - 12 derived from the activated DCs signaling the Vα14 iNKT cells.

«Indeed, small - molecule agonists of PPAR - delta mimic the effects of a high - fat diet in animals fed a normal diet,» Sabatini says.

Schubert U, Schmid J, Lehmann S, Zhang XY, Morawietz H, Block NL, Kanczkowski W, Schally AV, Bornstein SR, Ludwig B. Transplantation of pancreatic islets to adrenal gland is promoted by agonists of growth - hormone - releasing hormone.

Transplantation of pancreatic islets to adrenal gland is promoted by agonists of growth - hormone - releasing hormone.

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self - renewal.

Professor Wahl and his team have developed a platform cell - based assay in high - throughput format to screen for inhibitors and agonists of protein - protein interactions.

Using sazetidine - A as a template, medicinal chemists developed multiple series of novel ligands with modifications to the pyridine core, azetidine ring, and alkynyl side chain with the objective of designing α4β2 - nAChR partial agonists of high specificity.

Agonists of the µ - opioid receptor also have antidepressant effects (Berrocoso et al., 2009).

Not exact matches

In the past, researchers have looked into how one component of the experimental drug — GLP - 1 receptor agonists — affects people with Alzheimer's disease and Parkinson's disease.

Announced a clinical trial collaboration with Pfizer, Inc. (Pfizer) to evaluate the safety and efficacy of the investigational combination of Yescarta and Pfizer's utomilumab, a fully humanized 4 - 1BB agonist monoclonal antibody, in patients with refractory large B - cell lymphoma.

Results from a preclinical study conducted in collaboration with researchers at Beth Israel Deaconess Medical Center evaluating the combination of a proprietary investigational oral toll - like receptor 7 agonist, GS - 9620, and a proprietary investigational broadly neutralizing antibody, as part of an HIV eradication strategy.

Despite his disarming drollery, Saul Bellow has also accepted the role of agonist.

Weather you believe or not (I open my eyes every day) so it's not hard to All will stand before the lord on the day of reckoning which man will no doubtedly usher in and those who don't believe or against god will try to wage war on the almighty to no avail, only to be left in ruins... the great Satan (adversary) will be all who oppose god in battle, that serpent of old is still here today, we live in the middle of a brood of vipers and this website is part of the venom aimed at distorting the faithfuls belief as well as a an agonist for those who wish to continue to disbelieve... CNN is anti god To my brothers and sisters who truly live in Christ Peace be with you and never forget your path despite the darkness that is trying to consume you, bring enough oil for your lamps to live in this darkness and bring extra in case of a delay, he will not abandon you... we will not be forgotten Amen To those who don't, I know the myth of Santa and the easterbunny really choked up your insides to find that they were not real, but childhood is over and it was a cruel human joke designed to make it that much harder for you to believe in that which visits you and you can't see, no matter you have life so is it too much to ask for a little belief?

Dr. Shapiro's innovations also include the combination of GnRH agonist with low - dose hCG to realize the benefits of each trigger agent.

My central claim in the book is that the «ontological turn'taken by a number of thinkers of radical or agonist democracy, in the belief that reflecting on the essential dynamics of political being would engender a revivified understanding of possibilities for democratic action, created a particularly influential strand of socially weightless theorising.

This is particularly true in the case of synthetic cannabinoids receptor agonists, known by one of their popular brand names of Spice.

Thus, agonists hope that we can experience political engagement with pleasure and joy as well as the attending frustration that always comes with the friction of life in common.

I argued in my first book that even the best of such efforts always generate remainders and so we agonists must also be attentive to those and aware that a further politics must follow to redress that.

Agonists tend to emphasise the irreducibility of struggle in the political domain, but see politics as a way of holding a line in that struggle, between agonism and antagonism or outright conflict.

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot - Marie - Tooth disease type 2A

For a variety of male mammals, vasectomy (sometimes reversible) and castration are the most common contraceptive methods, though there has been success in some species with hormone suppressors called GnRH agonists.

First the binding strength of series of molecules is measured (the binding of so - called agonists and antagonists).

Delta9tetrahydrocannabinol, or THC, one of the main active ingredients in marijuanais an agonist, for instance.

«These results also provide a rationale to explore the clinical activity of an OX40 agonist antibody in combination with GSK2636771 in cancer patients with PTEN loss tumors.»

A Smo agonist stimulated and a Smo antagonist (cyclopamine) inhibited both phosphorylation of Smo by GRK2 and interaction of β - arrestin 2 with Smo.

Major determinants of alpha 2 - and beta 2 - adrenergic receptor agonist and antagonist ligand binding specificity are contained within the seventh membrane spanning domain.

«Countries using these measures should instead increase the availability of proven opioid - agonist therapies, such as methadone, and ensure there is adequate access to voluntary treatment programs in community settings and facilitate people with opioid addiction to seek treatment.»

To confirm this synergistic effect, the team measured serum levels of signaling proteins in tumor - bearing mice receiving OX40 agonist antibodies alone or in combination with GSK2636771.

These results suggest GSK2636771 treatment can «synergize» with OX40 agonist antibodies to augment effector functions of tumor - reactive T cells.»

«In our latest study, results suggest that the combination of an OX40 agonist antibody and GSK2636771 may induce robust and durable antitumor T - cell immunity,» said Weiyi Peng, M.D., Ph.D., assistant professor of Melanoma Medical Oncology, and co-lead of the study.

OCA is the first in a new class of drugs, farnesoid X receptor (FXR) agonists, and the response of the patients to OCA shows that abnormalities in the system it targets may be critical for this condition.

Those women with lower acute stress and lower dispositional anxiety benefit most from the administration of the vasopressin agonist.»

The TSRI scientists discovered the fundamental mechanism of the S1PR1 receptor, developed the chemical tools to synthesize both agonists and antagonists of the receptor, discovered the role of the receptor in the immune system's «cytokine storm» in pandemic influenza, and investigated the role of the receptor in type 1 diabetes.

«The results are relevant for clinical use of specific antibodies or related inhibitors in IL - 17RA dependent severe asthma, suggesting equal efficacy using either agonist or receptor blockade to treat severe asthma crisis,» said Ryffel.

Ozanimod blocks sources of inflammation in RMS by acting as a sphingosine 1 - phosphate 1 (S1PR1) receptor agonist.

TSRI owns several composition - of - matter patents that cover S1P agonist compounds including key patents that cover ozanimod.

A team including Roth and Brian Shoichet, a chemist at the University of California, San Francisco, who uses computer simulations to find new drugs, last year published details of a powerfully G - protein - biased µ - receptor agonist, PZM21.

Bohn noted isoquinolinone 2.1 is one example of a new class of «biased» kappa agonists that avoid many central nervous system side effects by preferentially activating a G protein - mediated signaling cascade without involving another system based on β - arrestin protein interactions.

Three distinct classes of drugs: dopaminergic agonists (such as D - amphetamine), serotonergic agonists (such as LSD), and glutamatergic antagonists (such as PCP) all induce psychotomimetic states in experimental animals that closely resemble schizophrenia symptoms in humans.

One of the more intriguing findings in the study was that increasing histone crotonylation works synergistically with other known anti-HIV latency molecules, such as the protein kinase C agonist PEP005 and the HDAC inhibitor vorinostat.