Sentences with phrase «agonists without»
Study 2 was a double - blind, randomized, placebo - controlled, parallel group, 18 - week study, investigating AZILECT 1 mg as adjunct therapy to dopamine agonists without levodopa.
https://www.azilect.com/
Key findings presented at AACR included sustained peripheral NK and T cell expansion, doses were well - tolerated and the drug candidate's role as a long - acting CD122 agonist without targeting CD25.
Ramelteon is a melatonin - agonist without the risks for dependence or addiction.
Not exact matches
Bohn noted isoquinolinone 2.1 is one example of a new class of «biased» kappa agonists that avoid many central nervous system side effects by preferentially activating a G protein - mediated signaling cascade without involving another system based on β - arrestin protein interactions.
Bohn said the new findings clearly demonstrate that the strategy of developing biased KOR agonists offers a promising new way to treat pain and intractable itch without the potential for abuse.
Perhaps partial agonists, directed at these receptor subtypes will have the greatest neuroprotective potential for they would have the ability to inhibit excessive receptor activity without totally shutting down the receptor's ability to perform normal neuronal functions.
AZILECT was studied as an adjunct therapy without levodopa (Study 2), or as an adjunct therapy to levodopa, with some patients also taking dopamine agonists, COMT inhibitors, anticholinergics, or amantadine (Study 3 and Study 4).
Wang D, Sun X, Sadee W. Different effects of antagonists on mu -, delta -, and kappa - opioid receptors with and without agonist pretreatment.
GW510516, a PPARd agonist retracts a number of abnormalities connected with the metabolic syndrome without escalating oxidative stress.
Indeed, this is underscore by the fact that some carefully controlled studies have reported that substantial early phase strength gains occur in as little as 5 days without changes in agonist muscle activation as measured by EMG amplitudes (Holtermann et al. 2005).