This colour contains
the Agouti gene which gives each individual hair a range of shades and produces a rich depth of colouring in the coat.
The absence of
the Agouti gene produces a silver coat with no hint of red, tan or cream.
The dog's coat color will be determined by
the agouti gene, and may pass on brindle or non-brindle.
The KB variant of the CBD103 gene promotes eumelanin (black pigment) synthesis by blocking
agouti gene expression at the A Locus which would otherwise inhibit MC1R production of eumelanin.
This dog carries two copies of KB which prevents expression of
the agouti gene (A locus) and allows for solid eumelanin (black pigment) production in pigmented areas of the dog.
Because KB is dominant, only one copy of KB is required to inhibit
agouti gene expression.
This dog carries two copies of ky which allows for the expression of
the agouti gene (A locus) which can result in a variety of coat colors including sable / fawn, tricolor, tan points, black or brown.
Genetic testing of the CBD103 gene for the KB variant will determine whether a dog is a genetic Carrier of
agouti gene expression.
Jirtle is well known for his work on mice that carry
the agouti gene, which is highly vulnerable to environmental influences.
They started with pairs of fat yellow mice known to scientists as agouti mice, so called because they carry a particular gene —
the agouti gene — that in addition to making the rodents ravenous and yellow renders them prone to cancer and diabetes.
The effects of
the agouti gene had been virtually erased.
After being consumed by the mothers, the methyl donors worked their way into the developing embryos» chromosomes and onto the critical
agouti gene.
Not exact matches
Normally, to achieve such a rapid evolutionary shift, a species needs to start with an alternative version of a
gene already in circulation, giving natural selection more to work with, but in deer mice the new version of
Agouti spread rapidly from a standing start.
The mutation was found in a
gene called
Agouti, which helps control coat colour in many mammals.
In Martin's view, the result strongly suggested that the patients had inherited the silenced
gene from one of their parents, like the case with
agouti mice.
In these species, the
gene agouti controls the relative amount of red and yellow pigments in the skin, and melanocortin 1 receptor (Mc1r) does the same for black and brown.
To identify
genes whose expression correlated with adiposity, we profiled
gene expression in perigonadal adipose tissue from 24 mice in which adiposity varied due to sex, diet, and the obesity - related mutations
agouti (Ay) and obese (Lepob).
In the first paper, utilizing genomic analysis of nearly 8,500 Icelandic and Dutch participants, the deCODE team identified a novel, tightly - linked pair of single - letter variants (SNPs) near the ASIP (
agouti signaling protein)
gene on chromosome 20 that greatly increase the likelihood of an individual being prone to freckles and sunburn.
The alternate ky variant of the CBD103
gene disrupts the normal function of the CBD103
gene allowing for
agouti (A locus)
gene expression and the inhibition of black pigment synthesis.
Dogs with one or two copies of KB will not express
agouti coat colors (sable / fawn, tricolor, black and tan, or tan points) and their coat color would be solid in pigmented areas as determined by the E and B
genes.
Sable in German Shepherds is a different
gene altogether (part of the
agouti series).
The most recessive version of K is ky; two copies of ky will allow another
gene, A (
agouti,) to express itself in a number of patterns commonly seen in other breeds, such as tan points.