Not exact matches
Normally, to achieve such a rapid evolutionary shift, a species needs to start with an alternative version of a
gene already
in circulation, giving natural selection more to work with, but
in deer
mice the new version of
Agouti spread rapidly from a standing start.
They started with pairs of fat yellow
mice known to scientists as
agouti mice, so called because they carry a particular
gene — the
agouti gene — that
in addition to making the rodents ravenous and yellow renders them prone to cancer and diabetes.
In Martin's view, the result strongly suggested that the patients had inherited the silenced
gene from one of their parents, like the case with
agouti mice.
To identify
genes whose expression correlated with adiposity, we profiled
gene expression
in perigonadal adipose tissue from 24
mice in which adiposity varied due to sex, diet, and the obesity - related mutations
agouti (Ay) and obese (Lepob).