Mapping the expression profiles of all genes one cell at a time revealed unexpected heterogeneity in the stem cell - derived lung cells, and the research team at the CReM used this information to improve
the airway cells engineered in the lab.
Not exact matches
Stem
cells that were
engineered to have higher amounts of Miro1 were able to transfer mitochondria more efficiently and were therapeutically more effective when tested in mouse models of
airway injury and asthma, compared to untreated
cells.
The
engineered cell culture enabled interaction between three
cell types of the
airways and reproduced their physiological interfaces — becoming essentially an «organ - on - chip.»