Not exact matches
This decline in PAL was significantly
associated with an increase in airflow obstruction (shown by a decline in FEV1) and an increase in total score on the St. George's Respiratory Questionnaire, which measures the impact of obstructive
airway disease on overall health, daily life, and perceived well - being.
It could be a critical target with significant therapeutic potential for suppressing inflammation
associated with chronic
airway disease.
While the mechanism by which a significant weight loss can reduce asthma -
associated risks is unknown, studies have linked obesity to increased inflammation, higher prevalence of gastroesophageal reflux
disease, and physical changes in the
airway — all of which could contribute to asthma severity.
Lead researchers
Associate Professor Chrishan Samuel and Dr Simon Royce tested the efficacy of the MSCs on three key components of asthma in a preclinical model of chronic allergic
airways disease: inflammation;
airway remodeling (structural changes that occur in lungs as a result of prolonged inflammation); and
airway hyperresponsiveness (the clinical symptom of asthma).
Read the full paper titled Intranasal administration of mesenchymoangioblast - derived mesenchymal stem cells abrogates
airway fibrosis and
airway hyperresponsiveness
associated with chronic allergic
airways disease published in the FASEB Journal.
Conclusion: Inflammatory
airway diseases and symptoms are
associated with CI and BRI, which encourages further research regarding underlying mechanisms and treatments.
Parent - reported physician - diagnosed asthma is
associated with more objective outcomes (eg,
airway hyperresponsiveness) and more severe
disease.33 Moreover, this definition is used by the National Center for Health Statistics in surveys of the US population to facilitate generalizability.34