Sentences with phrase «airway epithelial cells»

Olsen CE, Liguori AE, Zong Y, Lantz RC, Burgess JL, Boitano S. Arsenic upregulates MMP - 9 and inhibits wound repair in human airway epithelial cells.

My laboratory aims to identify, characterize and validate lncRNA - driven pathways active in allergy - driving helper T cells and airway epithelial cells that could hold promise as therapeutic targets in altering the aberrant immune responses underlying asthma.

Hypertonic Saline Primes Activation of the p53 — p21 Signaling Axis in Human Small Airway Epithelial Cells That Prevents Inflammation Induced by Pro-inflammatory Cytokines.

The research team then tested RMC - 1 in cultured human airway epithelial cells and mouse models of asthma (via injection into the animals» peritoneal cavities).

Microscopic images show that RMC - 1 prevented FOXM1 from entering the nucleus in cultured human airway epithelial cells and in mouse allergen - sensitized respiratory airways.

Because airway epithelial cells are tightly connected, the researchers posited that the membrane proteins on opposite sides don't normally mix.

But airway epithelial cells contain both molecules at all times, so researchers wondered what keeps healthy tissues from growing out of control.

Physical separation of the two proteins is an «easy - to - conceptualize mechanism by which airway epithelial cells are poised to heal themselves the moment they are injured.»

The airway epithelial cells that the method relies on are continuously shed, he notes.

Not exact matches

It then travels down the respiratory tract and binds to epithelial cells lining the lung airways via specific molecules on the cell surface.

Human nasal epithelial cells, cultured on a microchip, react to air pollutants just like they would in the upper airway.

«In our human airway epithelial model system, one of the drugs destabilizes and deactivates the protein that the other drug tries to correct,» said Martina Gentzsch, PhD, an assistant professor of cell biology and physiology and senior author of the UNC Science Translational Medicine paper.

They found that infection of the narrowest airways of the lung by PIV3 alone caused moderate levels of inflammation, but after infection by PIV3 expressing RSV NS2, the epithelial cells lining the narrow airways were shed rapidly into the airway lumen.

While the PIV - infected epithelial cells retained their natural elongated, columnar shape, the same cells infected with RSV balled up and puffed out of the airway epithelium, causing the infected cells to accumulate in the lumen of the airway.

Using animal models, Pickles has already found candidate molecular biomarkers that indicate if the epithelial cells in the tiniest airways are expressing the RSV NS2 protein.

In this case, AAV acts as a Trojan horse and leads epithelial cells in the airways to make the antibodies; the question is how long they will continue doing so.

«We compared the ability of RSV and parainfluenza virus (PIV3)-- another common virus in children that causes much less severe airway disease — to infect and cause inflammatory responses in a cell culture model of human epithelial cells, which compose the lining of the lung airway.

«But what we've now shown is that RSV has an increased ability to cause airway obstruction because, during an RSV infection, the virus expresses a specific RSV - encoded non-structural protein, or NS2, in epithelial cells, causing the cells to shed from the airway lining and into the airway lumen.

«It was known that the epithelial cells which line the airways in the lungs produce a protein called thymic stromal lymphopoietin (TSLP) that causes inflammation.

The human airway is lined with two kinds of epithelial cells — those that possess hairlike fringes called cilia and those that don't.

Local blockade of epithelial PDL - 1 in the airways enhances T cell function and viral clearance during influenza virus infection.

The higher scores (> 3) in some groups related primarily to the fact that virus infection had induced inflammatory infiltrates and epithelial cell necrosis with desquamation of the epithelium and collection of cellular debris in airways of these animals.

In the vaccine comparison experiment, lung lesion scores for histopathology were graded for individual animals on a scale of 0 to 4 where 0 — 2 represented degree of cellular infiltration and 3 — 4 represented the degree of bronchiolar epithelial cell necrosis and airway cellular debris (figure 2A).

Ciliary dyskinesis - This is a syndrome which has been reported in the Chinese Shar - Pei in which the cilia (microscopic hair - like projections on the epithelial cells which line the upper airways) are malformed or nonexistent.

ALI - FRECs morphologically resembled the natural airways of cats with multilayered columnar epithelial cells and cilia.