Sentences with phrase «airway inflammation in»

In addition, scientists in India found that curcumin could inhibit allergic airway inflammation in mice.

In one study, researchers at the University of Connecticut found that bromelain reduced airway inflammation in animals with allergic airway disease.

RIPK2 gene silencing in the airways decreased allergic airway inflammation in an ovalbumin - mediated mouse model of asthma (Jun et al., 2013).

Role of IL - 17A, IL - 17F, and the IL - 17 receptor in regulating growth - related oncogene - α and granulocyte colony - stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis.

This was the first study to assess inflammation on a tissue level and the first to discover airway inflammation in horses not specifically selected for poor performance.

seed extract on ovalbumin - induced airway inflammation in guinea pigs.

Not exact matches

Specifically, the researchers found that a peptide, called STAT6 - IP, when delivered to the lungs of neonatal mice at the time of first RSV exposure reduces the development of allergic - type lung inflammation and airway hyperresponsiveness («twitchy» airways) in mice when they are «re-challenged» with RSV as young adults.

Tobias Polte and his team from the Department of Environmental Immunology at the Helmholtz Centre for Environmental Research (UFZ) collaborated with Jan Simon and his colleagues from the Clinic for Dermatology, Venereology and Allergology at the University of Leipzig and have recently been successful in discovering a molecule that plays a significant role in the development of allergic airway inflammation — as demonstrated in their recent publication in Nature Communications.

UFZ researchers and their colleagues from the University of Leipzig have recently been successful in finding a protein that plays a critical role in the development of allergic airway inflammation.

Testing continues in laboratory models to better determine the VNN - 1 pathway's role in contributing to airway inflammation and hyper - responsiveness in asthma.

This leads to obstruction of airflow in the small airways and overwhelming inflammation.»

The findings, published in the online journal Scientific Reports, identify a novel mechanism that resveratrol, a compound found naturally in some plant foods such as grapes, uses to alleviate inflammation in airway disease.

In mice with asthma, AIP - 2 suppresses airway inflammation, Navarro and her colleagues report, and the protein also appears to damp down the proliferation of some immune cells in the blood of people with allergieIn mice with asthma, AIP - 2 suppresses airway inflammation, Navarro and her colleagues report, and the protein also appears to damp down the proliferation of some immune cells in the blood of people with allergiein the blood of people with allergies.

Cook - Mills had done previous allergy research in mice showing alpha - tocopherol decreased lung inflammation, protecting healthy lung function and gamma - tocopherol increased lung inflammation and airway hyperresponsiveness, a characteristic of asthma.

While the mechanism by which a significant weight loss can reduce asthma - associated risks is unknown, studies have linked obesity to increased inflammation, higher prevalence of gastroesophageal reflux disease, and physical changes in the airway — all of which could contribute to asthma severity.

T lymphocytes and NH cells in the asthmatic lung produce proteins named interleukin (IL)-5 and IL - 13 that are responsible for severe airway inflammation.

Some of the IgE - related genes were known to encode proteins produced by eosinophils, a type of white blood cell that promotes inflammation in asthma sufferers» airways.

In the current study, the researchers led by Drs Shigeo Koyasu from RIKEN and Koichiro Asano from Keio University, employed an experimental mouse model for airway inflammation to study the pathway leading to IL -33-mediated NH activation.

«It was known that the epithelial cells which line the airways in the lungs produce a protein called thymic stromal lymphopoietin (TSLP) that causes inflammation.

These cells are thought to kick - start inflammation in the lungs, which causes airways to narrow during an asthma attack.

There was also no significant reduction in other measured outcomes related to asthma control, airway function, quality of life, or airway inflammation.

Data suggesting that vitamin D supplementation could modify steroid response and reduce airway inflammation have led to questions about whether treatment with vitamin D might improve outcomes in patients with asthma, according to background information in the article.

Dulling nerve cells in mice's lungs soothes irritated airways by easing inflammation and out - of - control coughing, researchers report online June 25 in Neuron.

It also decreased airway hyper - responsiveness to allergen, reduced lung inflammation and improved lung function in mice sensitized to house dust mite allergens.

SPICE IT UP Pain - sensing fibers in a mouse's airways can excite the immune system and crank up inflammation.

In addition, reduced barrier function can let bacteria and other allergens enter the airways, increasing the risk of inflammation and infection.

Earlier findings by Dr Ferreira published in The Lancet identified that a risk factor for asthma was a genetic variant in the IL - 6 receptor, which is activated by IL - 6 causing inflammation in the airways.

Lead researchers Associate Professor Chrishan Samuel and Dr Simon Royce tested the efficacy of the MSCs on three key components of asthma in a preclinical model of chronic allergic airways disease: inflammation; airway remodeling (structural changes that occur in lungs as a result of prolonged inflammation); and airway hyperresponsiveness (the clinical symptom of asthma).

The study, published in the FASEB Journal, found that the MSCs could effectively reduce inflammation, reversed signs of airway remodelling and completely normalised airway / lung fibrosis and airway hyperresponsiveness, particularly when delivered intranasally.

Our finding of sinusitis, bronchial hyperreactivity, and bronchial responsiveness in firefighters with World Trade Center cough is important but not surprising.17 - 20 An unexpected finding was that 87 percent of such firefighters reported symptoms of gastroesophageal reflux disease; such symptoms are generally reported by less than 25 percent of patients with chronic cough.1, 21,22 Despite the strong associations between gastroesophageal reflux disease and chronic cough17 - 20 and between gastroesophageal reflux disease and asthma,23 - 25 it remains unclear whether gastroesophageal reflux disease causes either condition.26 The causative mechanism may be repeated aspiration of minute amounts of refluxed material; vagally mediated esophageal, tracheobronchial, or laryngobronchial cough reflexes; or neurally mediated bronchial inflammation.23, 24,26 Involvement of the posterior nasopharynx is common in patients with gastroesophageal reflux disease, 27 whereas bronchial hyperreactivity may not be present.25, 26 For these reasons, we classified gastroesophageal reflux disease as an upper - airway symptom (Figure 2).

Ma, X., Ma, X., Ma, Z., Wang, J., Sun, Z., Yu, W., Li, F., Ding, J. «Effect of Hyssopus officinalis L. on inhibiting airway inflammation and immune regulation in a chronic asthmatic mouse model».

Chronic airway inflammation is characterized by the infiltration of EOS, an increase in serum immunoglobulin (Ig) E and excessive secretion of airway mucus (4 — 6), which result in airway structural changes and may even develop into refractory asthma or severe asthma (7).

Previous studies have demonstrated that there are various levels of inflammatory responses in patients who suffer from asthma, and allergic airway inflammation with increasing EOS is the main pathological feature of asthma (20,21).

Asano T, Kume H, Taki F, et al: Thalidomide attenuates airway hyperresponsiveness and eosinophilic inflammation in a murine model of allergic asthma.

The variety of cell types present in BALF may reflect the degree of inflammation in the peripheral airways, which is also the main factor causing bronchial hyperresponsiveness in asthma (25).

Hypertonic Saline Primes Activation of the p53 — p21 Signaling Axis in Human Small Airway Epithelial Cells That Prevents Inflammation Induced by Pro-inflammatory Cytokines.

A role for dietary selenium and selenoproteins in allergic airway inflammation.

Leukotriene B4 release from mast cells in IgE - mediated airway hyperresponsiveness and inflammation.

It's no secret that smoking is harmful, but it's been hard to study its effects on chronic obstructive pulmonary disease (COPD), a disease that leaves sufferers short of breath thanks to inflammation of the small airways in the lung.

Enhanced Expression of Myristoylated Alanine — Rich C Kinase Substrate (MARCKS) in Airway Epithelium of an Animal Model of Allergic Airway Inflammation and Human Patients with COPD

Thus, targeting this chemokine receptor in patients with asthma might reduce Th2 cell - driven airway inflammation; therefore, CCR4 antagonists could be an effective new therapy for asthma.

Determining the mechanism for these sex - based differences in airway inflammation and the contribution of the microbiome in animal models would improve our ability to treat or prevent asthma and other autoimmune diseases in women.

He did his Ph.D from University of Pune in Biotechnology in identifying posttranscriptional regulation of cytokine IL - 10 and its effect on allergic airway inflammation.

Patients with COPD have airflow obstruction that is caused either by destruction of the air sacs that exchange gas in the lungs (emphysema) and / or inflammation of the airways (chronic bronchitis).

For sports recovery, Lindsay says salt therapy works on the well - documented phenomenon of an athlete's suppressed immune system and inflammation in their airways.

Your doctor may also prescribe an inhaled combination drug that is a steroid plus a long - acting bronchodilator like formoterol to relieve symptoms, along with drugs such as leukotriene modifiers that block body chemicals involved in airway inflammation.

In Chicago, my kids were using once - a-day Singulair pills; an inhaler for corticosteroids, like Flovent, to fight underlying lung inflammation; and the occasional inhaler with a bronchodilator, such as albuterol, to open up airways if they were coughing or having other symptoms.

In animal studies, Eric Secor of the University of Connecticut School of Medicine discovered that bromelain reduces the immune system's reaction to allergens and limits airway inflammation.

Allergic rhinitis is due to inflammation in the nasal airways.

Patients with asthma who ate a high - fat meal had increased inflammation in their airways soon afterward, and did not respond as well to treatment as those who ate a low - fat meal, the researchers found.