Large amounts of
alcohol can lead to / are connected to an increased amount of anemia,
alcohol dementia, brain shrinkage, physical dependence, sexual dysfunction, hormonal imbalance in men and women,
impaired prospective
memory, Wernicke - Korsakoff syndrome, insomnia, higher rates of major depressive disorder, alcoholism, and different types of cancer (pharynx, larynx, esophagus, breast, and colon and rectum in men).