Sentences with word «aldose»

The word "aldose" refers to a type of sugar molecule that contains an aldehyde group. These sugar molecules are commonly found in various foods and serve as a source of energy for our bodies. Full definition
«Working closely with Professor Srivastava and other UTMB faculty, the next step is to prove the safety and efficacy of aldose reductase inhibitors for these conditions and develop them to improve the health of millions of people,» said Jason Abair, associate vice president of the center.
In a hyperglycemic state, the affinity of aldose reductase for glucose rises, causing much sorbitol to accumulate.
«We've shown that oxidative signals can be blocked by aldose reductase, or AR, inhibitors,» said lead author Srivastava, who is a professor in UTMB's departments of biochemistry and molecular biology as well as ophthalmology and visual sciences.
Researchers have proved that a single «master switch» enzyme, known as aldose reductase, is key in producing excess mucous that clogs the airways of people with asthma and chronic obstructive pulmonary disease (COPD).
Kinostat ™ blocks aldose reductase which prevents the formation of sorbitol.
Quercetin Take this mainly if you have diabetic cataracts — Quercetin is an well known aldose reductase inhibitor.
[13] Mechanisms that may account for lipoic acid's benefit in preventing diabetic complications include prevention of protein glycosylation [14] and inhibition of the enzyme aldose reductase, the latter of which subsequently inhibits conversion of glucose and galactose to sorbitol.
The research, Srivastava said, shows that using aldose reductase, an enzyme, when used with doxorubicin, reduces the toxins that can damage the heart.
The next step, Srivastava said, is clinical trials of the drugs as a therapy for asthma and COPD — a process that should be expedited since aldose reductase inhibitors have already undergone Phase III clinical trials for diabetic neuropathy.
These end - products form when aldose and ketose sugars, along with lipid peroxidation by - products bind to vital proteins, compromising their functions.
Inhibitory Effects of Zingiber officinale Roscoe Derived Components on Aldose Reductase Activity in Vitro and in Vivo.
Any extra glucose that is absorbed into the lens is converted to sorbitol by an enzyme called aldose reductase.
When the glucose levels are high, hexokinase can not keep up and the excess glucose is metabolized by aldose reductase into sorbitol.
«The discovery that aldose reductase regulates mucus production and goblet cell metaplasia makes inhibition of this enzyme an attractive therapeutic option to reduce mucus - related airway obstructive diseases — and for the first time gives us a real chance to alter the course of the underlying disease in asthma and COPD.»
Using cell culture and laboratory mouse experiments, the researchers showed that the enzyme, aldose reductase, is essential to a process known as goblet cell metaplasia that is seen in both asthma and COPD.
«Aldose reductase is key to a whole range of inflammation disorders, so it comes as no surprise that it should be crucial to the inflammatory processes that drive disease in asthma and COPD,» said UTMB Health biochemistry and molecular biology professor Satish Srivastava, senior author of the paper.
«Also, aldose reductase inhibitors can be given orally, unlike current inhaler - based treatments, so medication compliance could be better.
According to Srivastava, aldose reductase inhibitors have a number of potential advantages over current therapies for asthma and COPD.
High - fat diet induced neuropathy of pre-diabetes and obesity: effects of «healthy» diet and aldose reductase inhibition.
Aldose reductase is the first enzyme in the sorbitol - aldose reductase (polyol) pathway [12] responsible for the reduction of glucose to sorbitol, as well as the reduction of galactose to galactitol.
Also, from Wikipedia re Sorbitol, the Polyol Pathway and Aldose Reductase: «While most cells require the action of insulin for glucose to gain entry into the cell, the cells of the retina, kidney, and nervous tissues are insulin - INdependent, so glucose moves freely across the cell membrane, regardless of the action of insulin.
Kinostat is an aldose reductase inhibitor that curtails sorbitol production.

Phrases with «aldose»

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