«We will see if these three monkeys can have
normal offspring.
However, the short - term survivors gave birth to
normal offspring, the team reports in tomorrow's issue of Current Biology.
February 14, 2008 DKK Health Registry Announcement January 17, 2008 News Update on prcd - PRA Testing in Europe January 8, 2008 Traduction en français des formulaires de demande de tests December 7, 2007 Normal to
Normal Offspring Tested at Reduced Prices
Most breeders select normal parents with normal grandparents, and expect to produce all
normal offspring.
With that ability, a breeder can move from a carrier parent to
a normal offspring in one generation of selection.
Expected average results based on at least 16 puppies: CARRIER to CARRIER breedings will produce 25 % AFFECTED offspring, 25 %
NORMAL offspring, and 50 % CARRIER offspring.
These findings are not unexpected given that study results for young offspring whose mothers had diabetes during pregnancy were indistinguishable from those for
normal offspring at this age.
Not exact matches
Strangely, in a few percent of the
offspring of Lolle and Pruitt's mutants, one copy of hothead spontaneously reverted to the
normal version, repairing its point mutation.
All developed normally and produced
normal trout
offspring.
If the drive hadn't worked, and
normal Mendelian inheritance rules were in effect, only 50 percent of male and no female
offspring would be yellow.
But mice dads that lacked this receptor in the epididymis had
offspring with
normal hormonal responses.
When an altered X chromosome is passed down to female
offspring, Gantz reasoned, the gene drive should convert the
normal X from the other parent into one with a broken yellow gene.
But the males — despite having smaller testes and lower sperm counts than
normal mice — were clearly fertile and produced
offspring.
Cress with two mutant copies of one gene seem to be able to correct the DNA they pass on, ensuring that at least a few of their
offspring revert to
normal.
The study revealed sex - specific, anxiety - like behaviour in the
offspring of both
normal - weight and obese pregnant mice exposed to the androgen dihydrotestosterone.
The team compared the
offspring of pregnant mice when given a low protein diet (8 per cent protein) and a
normal diet (20 per cent protein).
After they were weaned, all
offspring were given a
normal diet, and the team then looked at the difference in the
offspring's DNA methylation, from mothers exposed to low protein and those that were not.
These mice were then mated with females that hadn't been confined, and their resulting
offspring had higher blood glucose than
normal.
When Bordenstein and Brucker compared gene expression patterns in
normal and microbe - free
offspring, they found significant changes in many of the genes involved in the immune response (Science, doi.org/m87).
In 2001, a captive bonnethead shark (Sphyrna tiburo), a type of hammerhead shark (pictured), gave birth to a
normal - appearing female
offspring.
Instead, Lolle and Pruitt found that 1 % to 10 % of the
offspring produced
normal flowers, indicating that at least one copy of the mutant gene had reverted to the nonmutated wild - type.
This finding suggests that the
offspring may have a liver disease called cholestasis, which occurs when the
normal flow of bile is impaired.
The «extra-pair fertilizations» of
normal males in the monitored group resulted in a total of 68
offspring.
In the
normal course of affairs some of those
offspring will have traits that will help them survive a little longer than their brethren — a curve of the fin that helps a fish swim faster, a change in the eye that helps a bird spot its food.
The transgenic mice gave birth to fewer
offspring than their
normal relatives, which fits well with the evolutionary theory that there is a trade - off between longer life span and fertility.
The
offspring did not lose yield compared with durum wheat on
normal soils.
There is even a hint of evidence that
normal - looking eggs from a woman who also has these abnormal eggs may fail to yield
offspring.
Abraham Kierszenbaum of the City University of New York Medical School has conducted experiments in mice showing that even
normal - looking sperm from a mutant mouse «is likely to create infertile
offspring.»
The overexpression of inflammatory markers may be how pre-pregnancy alcohol use altered
normal glucose homeostasis in the
offspring, he stated.
Stressing surface fish with water chemically similar to cave water also yielded
offspring with a greater than
normal variety of eye sizes.
When these mice, which had
normal diets, had pups, however, the methylation patterns disappeared from their
offspring's DNA.
Importantly, the recovered males yield
normal and fertile
offspring.
An article by MIT Technology Review describes project «Boys Only,» in which Alison Van Eenennaam of the University of California aims to create a bull that will father only male
offspring: either
normal bull calves or ones with two X chromosomes but also the male - making SRY.
Dolly has since grown and reproduced several
offspring of her own through
normal sexual means.
Maternal history of T2DM was related to higher T2DM risk in
normal - weight subjects, and history of T2DM in the father was associated with higher T2DM risk in overweight subjects, without showing impact of sex of the
offspring.
None of the
offspring tested positive for the presence of the
normal KL2 gene carried by the gene therapy vector.
The male
offspring of an undernourished mother were, as expected, smaller than average and, if fed a
normal diet, went on to develop diabetes.
Interestingly, by analyzing the
offspring of IVC males mated with
normal females, it was observed that these characteristics were transmitted to the F1 and F2 males but not to females.
Acquiring a dog from a reputable breeder who uses Penn HIP or Orthopedic Foundation for Animals (OFA) techniques to evaluate the sire and dam's hip health can reduce the likelihood that the
offspring of
normal parents will develop hip dysplasia.
They only cause their health damage when both the (
normal looking) mother and father of the pup carry a single bad one and a single good one and the
offspring ended up getting a pair of two bad ones.
Dr. Donald Patterson, chairman of Medical Genetics at University of PA School of Veterinary Medicine, states that some dogs with radiographically
normal hips but a large number of hidden dysplasia - producing genes, if mated together, will produce at least some dysplastic
offspring.
However, two healthy dogs with
normal hearing can still produce deaf
offspring.
However, looking at our square we know that some of these «
normal» dogs actually have a phenotype of Pp, meaning that they are PRA carriers, and can pass the PRA affected gene to their
offspring.
In order to avoid producing crd2 - affected
offspring, at least one dog of any breeding pair should be homozygous
Normal / Clear (See chart below).
When clinically
normal dogs produce affected
offspring, it strongly suggests the disease is inherited as a simple recessive (or potentially a polygenic — multiple gene) trait, and both parents carry one «bad» copy of the gene causing the disease.
Normal dogs can breed and yield dysplastic
offspring as the condition may skip generations.
The aim is to replace the carrier breeding - animal with a
normal - testing
offspring that equals or exceeds it in quality.
The sire and dam's hip health can reduce the likelihood that the
offspring of
normal parents will develop hip dysplasia, and other problems.
It has been found and is common knowledge, that one can mate two parents with OFA rated excellent hips and have
offspring that are dysplastic; or mate two dysplastic parents and get pups with
normal to excellent hips.
For example, while it is possible for any Golden with
normal hips to produce dysplastic
offspring, a Golden Retriever with
normal hips from a litter where the majority of its siblings have hip dysplasia may be at particularly high risk to produce dysplastic
offspring.