They're not all rare variants, either: 86 million variants are classified as common (G5, G5A, or COMMON), with minor
allele frequencies > 1 % in at least one population.
Not so long ago, there was a hope in the research community that common genetic variation, i.e. variants present at minor
allele frequencies > 5 % in human populations, might explain most or all of the heritability of common complex disease.
We selected 1518 single - nucleotide polymorphisms (SNPs) with minor
allele frequency > 5 % in NO and CO signalling pathways.
Not exact matches
«SNPs usually have two
alleles: minor (with population
frequency < 50 %) and major (with population
frequency > 50 %),» said Gorlov, first author of the paper.
Six of 33 loci had an
allele with
frequency > 70 %, and
allele 202 at locus REN162C04 was homozygous in 101/102 dogs studied.
Illumina 170 K CanineHD datasets for English bulldog and Standard poodle were obtained from other GWAS studies [28, 29] and filtered for minor
allele frequency (< 0.05) and genotype (
> 90 %).
As predicted, neither
frequency of S
allele carriers of the 5 - HTTLPR nor cultural values of individualism — collectivism was significantly associated with either impulse control across nine nations or substance abuse across 12 nations (all p
> 0.05)(table 2).