Note that the loci represented are biased towards loci previously ascertained to show sharp
allele frequency differences between both ends of the subspecies distributions, and even for some of these we are able to detect introgressed alleles.
To identify signatures of geographically restricted natural selection, the authors searched for DNase I peaks containing variants with significant
allele frequency differences between individuals of African, European, and Asian ancestry.
Not exact matches
Among individuals with two divergent mitochondrial haplotypes (mt - haplotypes), the genome - wide analyses revealed significant
differences in nuclear
allele frequencies.
We did not find significant
differences or deviations in a consistent direction in the
frequency of derived
alleles in islands of divergence within O. c. cuniculus or in either subspecies when defining differentiation based on the proportion of fixed
differences versus shared polymorphisms (Figure 3); however, intervals of high FST in O. c. algirus did show a significant skew towards high
frequency derived
alleles.
The
differences between the samples are highest in low -
frequency alleles and decrease with increasing
allele frequency.
Recent studies emphasize that adiposity, like stature, is a polygenic trait, and that population genetic variability primarily comprises different
frequencies of particular
alleles, rather than major systematic
differences [14, 60].
This approach is most effective if many breeds are used or if mixed breed animals are used in addition to purebreds to reduce the false positives due to breed
differences in
allele frequencies.
There were no
differences in 5 - HTTLPR
allele frequency between the two groups (χ2 = 0.37, df = 2, and P = 0.83).