Sentences with phrase «alleles for»

Even though these data are preliminary, the results present an opportunity to utilize new genotyping information by screening potential sires and dams for the disease - associated alleles for these nine SNPs and combine this information with current orthopedic screening schemes in breeding strategies to help further reduce the prevalence of patellar luxation in this breed.

Dr. Tsai is currently sequencing dog leukocyte antigen class I and II loci and assigning alleles for a funded study to evaluate if certain alleles are associated with pancreatic acinar atrophy (EPI)

It is well known that purebred dog breeds are associated with differing susceptibility to specific malignancies, suggesting that selected breeds of dog are inheriting «at risk» alleles for very few genes, perhaps even a single gene, with a profound effect.

The dog does not carry the alleles for the black mask or recessive Red / Yellow.

The two most striking risk factors appear to be hyperinsulinism and possession of one or two E4 alleles for the apolipoprotein E gene (ApoE4), which is involved in lipid processing.

Use of common risk alleles for changes in clinical management can be challenging without a professional guideline.

Further, there are currently no validated ways of combining multiple risk alleles for the same disease.

Short guide RNA was targeted to the sequence corresponding to the CCHa2 peptide - coding region, resulting in the isolation of putative null alleles for CCHa2 (CCHa2CR - 1, CCHa2CR - 2, and CCHa2CR - 3)(Figs 5A and S5).

Gene engineering tools (`' One - StrepTagged» alleles for interactomics of primary immunocytes, cassette allowing the fast - track construction of multitask alleles, multicolor mice)

The alleles for «no tusks» were passed along over just a few generations.

Over 30 genetic susceptibility alleles for colorectal cancer have been pinpointed throughout the genome.

The alleles for lactose intolerance and lactose tolerance represent time - tested genes of the human race, just the opposite of the alleles of the Finnish Disease Heritage, which are native born and recent.

The team also found fewer singletons near alleles for blond hair and blue eyes, indicating that these traits, too, have rapidly spread over the past 2000 years, Field reported in his talk and on 7 May in the preprint server bioRxiv.org.

Instead, the alleles for almost all five resistance types were essentially unchanged.

When considering the founding kind pairs, we are looking at most to 4 alleles for each gene (1 / chromosome, 2 chromosomes / ndividual, 2 individuals).

The research by scientists at Children's Hospital Los Angeles and Columbia University shows a link between a particular allele for serotonin found at a higher frequency in those at risk of depression because of family history, and those who go on to develop major depressive disorder.

«For example, a breeder might succeed in adding a favorable allele for stem rust resistance from a wild barley, but along with that gene drag along another gene that causes shattering of the mature head,» Close said.

In contrast, the short - distance, performance - enhancing allele for the «speed gene,» MSTN, (39) was not observed in either of the predomesticated horses.

These false hits can arise when cells select one allele for other reasons — it could be random or specific to the allele's sequence, rather than its parent of origin.

This plot shows the distribution of mate pairs that support reference allele for MEI events detected by the 1000 Genomes Project that were also detected in the sequenced genome.

Preclinical evidence of Alzheimer's disease in persons homozygous for the e4 allele for apolipoprotein E. NEJM 1996; 334 (12): 752 - 758.

Shiloh has inherited a recessive allele for a genetic trait or mutation.

The dogs that lack the specific dominant E allele for those dark coats will have hair limited to the various shades of red / tan / fawn («yellow»).

The identification of the causative allele for canine narcolepsy was made possible by the establishment of a colony of narcoleptic Dobermanns and Labradors.

Making it more complicated, in order to have E express itself as a black coat, it is necessary to also have the As allele for self - or solid - black at the A locus.

The A-1 allele of the DRD2 gene is considered the risk allele for antisocial phenotypes.

Not exact matches

For example, population processes associated with colonization, periods of geographic isolation, socially reinforced endogamy, and natural selection all have affected allele frequencies in certain populations (Jorde et al. 2000b; Bamshad and Wooding 2003).

So in the cited reference, even though we start with 4 alleles, we know that for many, many genes, 3/4 would be lost, forever, after a few generations.

Although the probability of a parent donating one or the other allele to an offspring is for the most part 50/50, the actual donations do not reflect this.5 probability (e.g. consider how many families have all boys or all girls).

Until recently, half of the human race died from infectious causes before adulthood, providing strong selective pressure for genetic alleles that enhance host defence but why are the genetic alleles that are most frequently associated with depression so common in the modern gene pool?

The TAS2R8 gene's two most common alleles are for tasting and nontasting.

«This study reveals for the first time a comprehensive picture of all active alleles in different tissues — we have uncovered the first complete allelome» Florian Pauler, now at ISTA (Institute of Science and Technology Austria) and co-senior author, adds.

For their experiments, the researchers created hybrids of two genetically distinct mouse strains with a fully sequenced genome, allowing gene variants to be clearly assigned to the maternal or paternal allele.

Using Atlantic killifish (Fundulus heteroclitus), the researchers examined whether mitochondrial - nuclear interactions alter the frequency of alternative forms of a gene that arise by mutation, called alleles, for over 11,000 nuclear DNA sequence variations within a population of the fish with mixed ancestry.

However, for a few genes, only one allele is expressed, while the other one is silenced.

The decision whether the maternal or the paternal version is shut down occurs early in embryonic development — one reason, why for long it was thought that the pattern of active alleles is nearly homogeneous in the various tissues of the organism.

Individuals were classified as high risk for Alzheimer's if a DNA test identified the presence of a genetic marker — having one or both of the apolipoprotein E-epsilon 4 allele (APOE - e4 allele) on chromosome 19 — which increases the risk of developing the disease.

Specifically, they found that in warmblood horses, which are bred for equestrian sport, mares exposed to stallions with dissimilar MHC alleles were more likely to get pregnant than those exposed to MHC - similar males.

They also note that there are alleles «consistent» with those known to call for brown hair and brown eyes.

His group has found, for example, that APOE3 — by far the most common APOE allele in humans — is usually inherited either with a short or a very long 523 tract.

By reading thousands of alleles and estimating mutation rates, the duo can work out the separation date for each allele and calculate past population sizes.

The team looked for patterns associated with two COLIA1 alleles, called S and s. Women who had one copy of the s allele had bone density in the thighbone and lower spine that was 2 % less than that of women with no s alleles.

«Carriers of this allele had a roughly 2-fold increase in risk for PTSD.»

«For the first time, we developed a sequence - specific and clinically feasible method to activate expression of the paternal Ube3a allele,» said the authors in the report.

The study found that among those at low risk for depression, the «S» (short) allele is associated with a thinner cortex than those with the «L» (long) allele.

For example, they revealed that most organisms have two copies of each gene, one from each parent, and that a gene comes in a variety of different forms, or alleles.

For example, he lumps together competition between genetically identical cells and competition between alleles in a population.

A purebred tall pea plant has two tall alleles of a gene for height (often abbreviated as TT), and the short plants have two short alleles (tt).

Genetic tests revealed that all ants in a monogyne colony have two copies of the B allele, but among the polygynes, at least 10 % are heterozygous, carrying a mutant allele, b, which Krieger says appears to code for a faulty protein.

With sexual reproduction, you will hopefully get a new combination of gene alleles that is more fit for whatever is coming down the pike,» King said.