Sentences with phrase «alleles on»

Although few of the alleles in the island skunks were unique, frequencies of the alleles on the islands were substantially different from those on the mainland.

The dog's color can vary greatly with different mutated alleles on other genes.

Many of the strains received have been made congenic, including 87 alleles on a C57BL / 6NCrl background, and several on other backgrounds including BALB / cJ and 129S6 / SvEvTac.

If the ARMD and PGx variants were also considered, each individual carried 15.3 risk alleles on average.

People who carry too long alleles on the serotonin transporter gene, tend to avoid negative influences and look on the bright side; those with the short version were more negative.

MCR uses the initial mutated allele to cause a mutation in the allele on the opposing chromosome and thus the homozygosity of the trait.

The analysis supports earlier findings that people who had a less functional short allele on a certain area of the serotonin gene had a more difficult time recovering from trauma compared to those with long alleles.

With the advent of micro-satellite markers in late 1990's Bedlington CT came to be associated with the presence of what is known as the 2 - 2 C04107 allele on a particular chromosome.

The dog can pass either allele on to any offspring.

That would mean that both the Sire and the Dam would have to contribute a recessive b allele on to the puppy in order for it to be a Chocolate Labrador.

Twenty years after the colony was established at Stanford University, linkage analysis identified the causative allele on the hypocretin receptor 2 (hcrtr2) gene [86].

Not exact matches

Some genes have a variety of different forms, which are located at the same position on a chromosome; an allele is such a variant form of a gene.

Dr. Kshirod K. Jena, a principal scientist at IRRI whose research has been on breaking the yield barrier of rice using genomics strategy, and his team discovered that the gene Gn1a - type 3 allele had not been very effective in indica cultivars.

Also, while it is true that Africa is the most genetically diverse, that does not preclude positive or purifying selection acting on very specific alleles, including those related to childbirth, across the continent, or across wide swathes of the continent (the latter being more likely).

Individuals were classified as high risk for Alzheimer's if a DNA test identified the presence of a genetic marker — having one or both of the apolipoprotein E-epsilon 4 allele (APOE - e4 allele) on chromosome 19 — which increases the risk of developing the disease.

In those who inherit two APOE3 alleles, age of onset differs depending on which combination of the two 523 variants they also inherit.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

Malaria, on the other hand, ebbs and flows over time, so the physiological benefits associated with the sickle - cell allele may be tempered.

The research by scientists at Children's Hospital Los Angeles and Columbia University shows a link between a particular allele for serotonin found at a higher frequency in those at risk of depression because of family history, and those who go on to develop major depressive disorder.

This may be a reason why the 313 blacks in the study had poorer responses on average — only 6 % of them had at least one A allele, compared with 42 % of the whites.

Their further analysis also provide evidence on the ancestral status of the Indian group, which holds great potential for introducing new alleles into the cultivated gene pool.

He only passes on the m allele, so his children are more likely to have the mm combination of alleles themselves.

Testing for a single marker doesn't tell you much about the person's background, because that one allele, whatever form it takes in the person, probably occurs in every band of people on Earth.

Around the world, innovative genomic - medicine programs capitalize on singular capabilities arising from local health care systems, cultural or political milieus, and unusual selected risk alleles or disease burdens.

To understand why the C allele has an effect on obesity, the study team carefully examined the genetic area that differs between C and T alleles.

For the current study, the Stowers researchers focused on a differentially imprinted control region, which drives the reciprocal expression of H19 from the maternal allele and Igf2 (Insulin growth factor 2) from the paternal allele.

The team also found fewer singletons near alleles for blond hair and blue eyes, indicating that these traits, too, have rapidly spread over the past 2000 years, Field reported in his talk and on 7 May in the preprint server bioRxiv.org.

Initially the people who drank milk from cows had something unusual about them, but by chance the new allele improved the welfare of human beings on their way north.

The more intense the selection on an allele, the faster it spreads, and the less time there is for singletons to accumulate near it.

Because alleles carry neighboring DNA with them as they circulate, the number of singletons on nearby DNA can be used as a rough molecular clock, indicating how quickly that allele has changed in frequency.

If a mother has two different versions, or alleles, of a gene, conventional genetic testing can't work out which allele she passed on to her child, because her blood contains both.

The vitality of a bee population depends on, amongst other things, the genetic diversity of sex determining alleles.

With the advent of more and more sophisticated ways to measure genetic variation and relatedness using molecular markers, such as allozyme polymorphisms and DNA - based markers, not only can individuals be tracked as to their parentage, but changes in allele patterns over time and thus the effects of evolution on populations can be «seen» in the genetic information.

The queen bee, who, in the course of their mating flight, mate with different drones multiple times, passes on to fertilized eggs a random combinations of two csd copies, so - called alleles.

The enhancer is chosen based on the category, and class I sensory neurons activate one enhancer allele of the J element (green or red circle).

Because MHC alleles differ in their binding affinity for various peptides, a vaccine based on just one peptide may not work for everyone.

The alleles in question were found on two different haplotypes — a set of alleles inherited by an individual from a single parent — in unrelated individuals.

Stratification of endurance and sprint athletes based on sport classification resulted in significant genotypes and allele frequencies (Table 3).

In a sample with 26.9 % of CXCR4 alleles disrupted, NHEJ events were detected at a frequency of 2.3 % (170/7531 reads) in an extragenic region on chromosome 12 and 0.8 % (84 / 10531) in ADAMTS17, a metalloprotease of unknown function [45].

Altogether, the haplotypes of the three ancient samples were classified as either dog or wolf - like for 18 matrices that showed clear distinction between dog and wild canid haplotypes based on average reference allele counts calculated per window.

Thus, the survival of XpdTTD / † XPCS (and XpdTTD / † XP) cells likely represents a level of UV resistance that neither mutant allele can impart on its own (Table 2).

Our data suggest that certain presumed null alleles, although unable on their own to support basal transcription, may in fact have a substantial impact on disease outcome in compound heterozygous humans, as they do in mouse models.

Estimating inbreeding coefficients from NGS data: Impact on genotype calling and allele frequency estimation.

In this view, allele counts (from individual or pooled specimens) for commonly assayed loci are displayed on the map as donut charts.

Interallelic complementation is defined as the ability of two differentially mutated alleles to function better together than either can on its own.

By combining SNP - targeting allele - specific silencing and gain - of - function approaches, we showed that a 46 - glutamine expansion in human HTT was sufficient for a dominant - negative effect on spindle orientation and changes in the distribution within the spindle pole and the cell cortex of dynein, p150Glued and NuMA in neural cells.

All registered alleles etc. will remain reserved, but not public on the MGI website, until they appear in any publication, or the strain is made public on the INFRAFRONTIER website.

We report a variety of biallelic effects on organismal phenotype attributable to combinations of recessive Xpd alleles, including the following: (i) the ability of homozygous lethal Xpd alleles to ameliorate a variety of disease symptoms when their essential basal transcription function is supplied by a different disease - causing allele, (ii) differential developmental and tissue - specific functions of distinct Xpd allele products, and (iii) interallelic complementation, a phenomenon rarely reported at clinically relevant loci in mammals.

Double - strand validation was also used to check that the heteroplasmic alleles were present on both DNA strands at a frequency of at least 1 % [20, 38].

Although interallelic complementation between two endogenous mutant alleles has been described in cells from a compound heterozygous patient with methylmalonic acidaemia, no observable effects on disease outcome were noted in the patient [28].