Sentences with phrase «allelic effects»

Allelic effects at the major gene locus showed nearly to complete dominance, with a recessive, unfavourable allele in both traits.

Unfortunately, a decade after the popularization of GWAS and in spite of much effort, we have fallen short of the goal of explaining most of the heritability for complex traits in terms of allelic effects.

Many of the allelic effects in the QTL were driven by the two founders with underrepresented subspecific origins, including a QTL on chromosome X for infertility that was driven by the PWK / PhJ haplotype.

When the average allelic effect does not capture a specific allelic effect under certain conditions, whether due to genetic background or environmental effects, current methods will not detect the link between genotype and phenotype.

Not exact matches

The authors conclude that»... by 4400 years ago, early farmers had already had a substantial homogenizing effect on allelic diversity at three genes associated with maize morphology and biochemical properties of the corn cob.»

Reduced allelic diversity and heterozygosity are expected consequences of founder effects, genetic drift, and inbreeding, which are associated with colonization and subsequent small population size (Frankham 1997, 1998).

(b) In the mediation regression where both S allelic frequency and cultural value of individualism — collectivism were included as predictors of global depression prevalence across 12 nations, individualism — collectivism remained a reliable predictor (β = − 0.21, p < 0.05), and the effect of S allele frequency decreased significantly (from r (12) = − 0.51 to r (12) = − 0.03; Sobel test Z = − 1.92, p < 0.05).

In the mediation regression where both historical pathogen prevalence and S allelic frequency were included as predictors of cultural values of individualism — collectivism across 29 nations, S allelic frequency remained a reliable predictor (β = 0.45, p < 0.007), and the effect of global historical pathogen prevalence decreased significantly (from r (29) = 0.72 to r (29) = 0.42; Sobel test Z = 2.28, p < 0.05).

In the mediation regression where both S allelic frequency and cultural values of individualism — collectivism were included as predictors of global anxiety prevalence across 12 nations, individualism — collectivism remained a reliable predictor (β = − 0.24, p < 0.05), and the effect of S allele frequency decreased significantly (from r (12) = − 0.55 to r (12) = − 0.08; Sobel test Z = − 1.60, p = 0.05)(figure 3a).

More importantly, however, it will be crucial to determine (1) how this functional locus interacts with the allelic expression imbalance markers downstream (and which the actual locus conferring allelic expression imbalance is, see in what follows)(2), what the relative contribution to a net effect on serotonin transporter gene expression is in vivo and (3) how (if at all) this translates into protein abundance and actual genetically determined differential functioning of the serotonergic synapse.

Similarly, in the mediation regression where both S allelic frequency and cultural value of individualism — collectivism were included as predictors of global depression prevalence across 12 nations, individualism — collectivism remained a reliable predictor (β = − 0.23, p < 0.05), and the effect of S allele frequency decreased significantly (from r (12) = − 0.51 to r (12) = − 0.01; Sobel test Z = − 1.92, p < 0.05)(figure 3b).

Next, the primary research questions were addressed by examining the moderating effects of allelic group on task - specific brain activation.

During the outcome phase (during presentation of feedback), the contrast of interest was the effect of allelic groups on differences in brain activation for reward versus non-reward trials.

During the anticipation phase (the time between presentation of cues and potential reward receipt), the contrast of interest was the effect of allelic group on differences in brain activation for incentive versus non-incentive trials.