Sentences with phrase «allelic expression»

Expression studies have demonstrated that in female skin fibroblasts the MAOA gene undergoes X-inactivation and shows mono - allelic expression [21].

More importantly, however, it will be crucial to determine (1) how this functional locus interacts with the allelic expression imbalance markers downstream (and which the actual locus conferring allelic expression imbalance is, see in what follows)(2), what the relative contribution to a net effect on serotonin transporter gene expression is in vivo and (3) how (if at all) this translates into protein abundance and actual genetically determined differential functioning of the serotonergic synapse.

For instance, the mono - allelic expression of imprinted genes shows that two alleles exposed to the same transcription factors can have opposite transcriptional states.

He has focused on leveraging allelic expression data to quantify regulatory variation within individuals.

Not exact matches

Allelic variation in this transporter's gene expression, regulated by a 43 bp indel in the upstream region termed 5 - HTTLPR, was initially associated with anxiety - related traits (23) and has since been investigated in many fields of serotonin - related human genetics (24).

CONCLUSIONS: These results suggest that the behavioral expression of allelic variation in MAOA activity is sensitive to social experiences early in development and that its functional outcome might depend on social context.