The research, conducted by Ivan P. Gorlov, PhD, Olga Y. Gorlova, PhD, and Christopher I. Amos, PhD of the newly
formed Department of Biomedical Data Science, was shared in «
Allelic Spectra of Risk SNPs Are Different for Environment / Lifestyle Dependent versus Independent Diseases,» and published in PLOS Genetics.
In humans, disease susceptibility was mapped to a non-coding 6.1 kb 3» region of CTLA4, the common
allelic variation of which was correlated with lower messenger RNA levels of the soluble alternative splice
form of CTLA4.