Sentences with phrase «allelic frequencies in»

Based on differences in imputed nsSNP allelic frequencies in different genetic backgrounds, likelihood measurements were calculated for European relative to African genetic backgrounds, with distinct patterns emerging as a function of genetic background.

The different FY allelic frequencies in individuals from North compared to Southeastern Brazil, may be due to the contribution of the three major ethnic groups (Europeans, in particular Portuguese; Blacks and Amerindians) in the formation of both populations.

Not exact matches

Therefore, we assessed the genotype and allelic frequency of this SNP in elite athletes participating in 11 different sports differing in dependence on endurance.

Second, the spatial distribution of allelic frequencies across the hybrid zone revealed a subset of coincident, narrow and stepped clines consistent with reproductive barriers acting to prevent introgression in a fraction of the genome, but also that cline width varied by a factor of 50 with introgressed alleles often reaching the distribution ends of both subspecies [27](Figure S2).

Given that ovulatory dysfunction is a key feature of PCOS, one group investigated a cohort of PCOS patients to determine if there was an association with this polymorphism.68 They reported significant differences in the genotype distribution and allelic frequencies between controls and PCOS patients that supported a correlation with the G / A polymorphism.68 To date, the underlying mechanism has not been established.

Mitogenomes can recover patterns at greater time depths than microsatellites, which are likely to reflect recent and dramatic changes in nuclear allelic frequencies caused by genetic drift [14,17].

To further determine the specificity of the mediating role of collectivistic cultural values on the association between allelic frequency of the 5 - HTTLPR and mental health disorders, we also conducted regression of mediation on 5 - HTTLPR, individualism — collectivism and two mental health disorders included in the 2008 WHO Mental Health Survey, but not previously associated with the 5 - HTTLPR, namely substance abuse and impulse control.

(b) In the mediation regression where both S allelic frequency and cultural value of individualism — collectivism were included as predictors of global depression prevalence across 12 nations, individualism — collectivism remained a reliable predictor (β = − 0.21, p < 0.05), and the effect of S allele frequency decreased significantly (from r (12) = − 0.51 to r (12) = − 0.03; Sobel test Z = − 1.92, p < 0.05).

Importantly, in the current study, divergent validity analyses indicated that cultural values and allelic frequency of the serotonin transporter gene predicted global prevalence of anxiety and mood disorders, but not impulse control and substance abuse.

Analyses were conducted using aggregate published data on allelic frequency of 5 - HTTLPR, cultural values of individualism — collectivism and global prevalence of anxiety and mood disorders, which refers to bipolar disorder, dysthymia and major depressive disorder defined by DSM IV / CIDI criteria in the 2008 World Health Organization (WHO) survey, with nation as the cultural unit of analysis.

Data on allelic frequency of the 5 - HTTLPR from 50 135 individuals living in 29 countries (Argentina, Australia, Austria, Brazil, Denmark, Estonia, Finland, France, Germany, Hungary, India, Israel, Italy, Japan, Korea, Mexico, the Netherlands, New Zealand, Poland, People's Republic of China, Russia, South Africa, Singapore, Spain, Sweden, Taiwan, Turkey, UK and USA) were compiled from 124 peer - reviewed publications (see table S1 and methods in electronic supplementary material for further detail).

In the mediation regression where both historical pathogen prevalence and S allelic frequency were included as predictors of cultural values of individualism — collectivism across 29 nations, S allelic frequency remained a reliable predictor (β = 0.45, p < 0.007), and the effect of global historical pathogen prevalence decreased significantly (from r (29) = 0.72 to r (29) = 0.42; Sobel test Z = 2.28, p < 0.05).

In the mediation regression where both S allelic frequency and cultural values of individualism — collectivism were included as predictors of global anxiety prevalence across 12 nations, individualism — collectivism remained a reliable predictor (β = − 0.24, p < 0.05), and the effect of S allele frequency decreased significantly (from r (12) = − 0.55 to r (12) = − 0.08; Sobel test Z = − 1.60, p = 0.05)(figure 3a).

Here, we examined the association between cultural values of individualism — collectivism and allelic frequency of the serotonin transporter functional polymorphism (5 - HTTLPR) as well as the role this culture — gene association may play in explaining global variability in prevalence of pathogens and affective disorders.

Similarly, in the mediation regression where both S allelic frequency and cultural value of individualism — collectivism were included as predictors of global depression prevalence across 12 nations, individualism — collectivism remained a reliable predictor (β = − 0.23, p < 0.05), and the effect of S allele frequency decreased significantly (from r (12) = − 0.51 to r (12) = − 0.01; Sobel test Z = − 1.92, p < 0.05)(figure 3b).