Asthma and
allergic airway hyperresponsiveness is a serious public health concern.
Allergic airway hyperresponsiveness - enhancing γ $ ẹlta $ T cells develop in normal untreated mice and fail to produce IL - 4 / 13, unlike Th2 and NKT cells.
Not exact matches
Specifically, the researchers found that a peptide, called STAT6 - IP, when delivered to the lungs of neonatal mice at the time of first RSV exposure reduces the development of
allergic - type lung inflammation and
airway hyperresponsiveness («twitchy»
airways) in mice when they are «re-challenged» with RSV as young adults.
Lead researchers Associate Professor Chrishan Samuel and Dr Simon Royce tested the efficacy of the MSCs on three key components of asthma in a preclinical model of chronic
allergic airways disease: inflammation;
airway remodeling (structural changes that occur in lungs as a result of prolonged inflammation); and
airway hyperresponsiveness (the clinical symptom of asthma).
Read the full paper titled Intranasal administration of mesenchymoangioblast - derived mesenchymal stem cells abrogates
airway fibrosis and
airway hyperresponsiveness associated with chronic
allergic airways disease published in the FASEB Journal.
Asano T, Kume H, Taki F, et al: Thalidomide attenuates
airway hyperresponsiveness and eosinophilic inflammation in a murine model of
allergic asthma.