Sentences with word «allogeneic»
The word "allogeneic" refers to something that comes from another person or organism, rather than from oneself. Full definition
Graft - versus - host disease (GVHD) is a long - term side effect that occurs in about half of allogeneic stem cell transplant patients.
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The only documented long - term complete remissions reported in multiple myeloma patients have occurred with allogeneic bone marrow transplantation, where a donor's blood stem cells (graft) are transplanted into the patient (host) with multiple myeloma.
Peripheral blood stem cells are generally used in autologous transplantations, while either marrow or peripheral blood stem cells are used in allogeneic transplantations.
Clinical trial research is also ongoing to evaluate the safety of allogeneic hematopoietic cell transplantation — using cells taken from healthy donor tissue — for HIV - infected patients with blood cancers.
Besides the ethical concerns of stem cell therapy, there is a technical problem of graft - versus - host disease associated with allogeneic stem cell transplantation.
That's exciting because it provides strong evidence that this miR may be a good target for controlling cGVHD after allogeneic BMT.»
In the future, outpatient blood and bone marrow stem cell transplantation will be offered to a broader group of patients with other blood disorders and for allogeneic transplants (transplant from non-twin donor stem cells).
Donor - type CD4 (+) CD25 (+) regulatory T cells suppress lethal acute graft - versus - host disease after allogeneic bone marrow transplantation.
Sioud M, Mobergslien A, Boudabous A, Fløisand Y. Evidence for the involvement of galectin - 3 in mesenchymal stem cell suppression of allogeneic T - cell proliferation.
Collaboration with Hematology and Bone Marrow Transplantation Unit research group in molecular diagnostics applied to the management of patients undergoing allogeneic SCT, especially for the detection of minimal residual disease and early relapse.
Should all patients with Hodgkin lymphoma who relapse after autologous SCT be considered for allogeneic SCT?
Finally, the future success of autologous transplantation of genetically repaired or in vitro expanded organoids in patients, abolishing the need for allogeneic donors and for lifelong immunosuppression, is dependent on a significant improvement in engraftment efficiency.
The characteristic cytokines produced by Th1 and Th17 cells also were elevated in serum from allogeneic recipients (Supplemental Fig. 1G).
With 30 to 70 percent of patients who receive allogeneic BMT developing cGVHD, the lack of effective therapies is a major unmet clinical need.
The present demonstration of T cell - mediated apoptosis of allogeneic corneal cells from CD4 KO mice is consistent with previous findings, which noted the presence of apoptotic keratocytes and corneal endothelial cells in rejected corneal allografts in humans and rats respectively (5, 32).
Data supporting the contention that MSC avoid allogeneic responses has also come from a large body of in vitro experiments, usually involving co-culture or mixed lymphocyte reactions (MLR).
Compared with the toxicity that we see with allogeneic donor hematopoietic stem cell therapy, these toxicities are relatively manageable with close monitoring and close supportive care.
Their combination strategy involves allogeneic mesenchymal stem cells (MSCs) that provide trophic support to stimulate the cartilage - producing activity of patient - derived chondrons (chondrocytes with their native matrix) isolated while preparing the damaged cartilage for repair.
For instance, during emergency care, allogeneic therapy is usually the only relevant option due to the time constraints of autologous cell expansion.
MSC appear to evade allogeneic rejection by (a) being hypoimmunogenic; (b) modulating T cell phenotype and (c) creating an immunosuppressive local milieu.
Human mesenchymal stem cells modulate allogeneic immune cell responses.
With a focus on allogeneic human stem cells for human therapeutic use — the largest and most «scale - ready» therapeutic class of cells — below we review, analyze, and synthesize decision - support and optimization tools for large - scale cell therapy bioprocessing with a goal of achieving the following objectives:
Burmeister DM, Stone R, Wrice N, et al., Delivery of Allogeneic Adipose Stem Cells in Polyethylene Glycol ‐ Fibrin Hydrogels as an Adjunct to Meshed Autografts After Sharp Debridement of Deep Partial Thickness Burns.
Lethally irradiated BALB / c recipients were transplanted with 5 × 106 TCD - BM cells plus 1 × 106 spleen T cells (H - 2b) from B6 mice (allogeneic group [Allo]; n = 15) or the same number of TCD - BM and spleen T cells (H - 2d) from BALB / c mice (syngeneic group [Syn]; n = 10).
In the meantime, the MUSC team, led by Yu, will continue their work and try to extend the current findings by investigating how other miRs may be involved in regulating T - and B - cell function during allogeneic BMT.
Anti-CD13 Abs in children with extensive chronic GVHD and their relation to soluble CD13 after allogeneic blood and marrow transplantation from a Children's Oncology Groups Study, ASCT0031.
Mehta J, Gordon LI, Tallman MS, et al., Does younger donor age affect the outcome of reduced - intensity allogeneic hematopoietic stem cell transplantation for hematologic malignancies beneficially?
Additionally, MSCs have been reported to induce the formation of CD8 + Tregs that are responsible for the inhibition of allogeneic lymphocyte proliferation 41.
Experiments involving allogeneic co-cultures or MLR have demonstrated that both cell - cell contact and action by soluble factors contribute to the immunomodulatory function of MSC 106, 107, 108, 109.
Our AST - VAC2 program further increases this scalability through the use of our pluripotent stem cell platform for the production of allogeneic dendritic cells for off - the - shelf availability on demand
Immediately following allogeneic transplantation, patients are immunosuppressed and unable to fight infection.
The apparent eradication of HIV resulting from a ccr5Δ32 homozygous allogeneic bone marrow transplant into an HIV - infected patient represents the first reported «cure» of HIV [6].
These strategies may provide clues to how MSC promote tolerogenic mechanisms during allogeneic engraftment.
CpG stimulation of precursor B lineage acute lymphoblastic leukemia induces a distinct change in costimulatory molecule expression and shifts allogeneic T cells towards a Th1 response.
(A and B) Flow cytometry analysis of intracellular IFN - γ and IL - 17A on donor - derived CD4 + T cells from spleen on indicated days for syngeneic and allogeneic mice.
«From this data, it's clear that we have to make strides in supporting allogeneic BMT recipients in their recovery to ensure that we are educating patients and their families on signs of cognitive impairment.
The capacity of DN T cells to kill allogeneic target cells in vitro and mediate tumor allograft rejection in vivo has been previously reported by Young et al. (37).
(C) Immunogenicity of PSC - derived CTP: recipient response to allogeneic CTP in non-human primate models of HD (in collaboration with Dr Hantraye / Aron - Badin and Pr E Cozzi, Padova, Italy)
Capricor has autologous and allogeneic Phase 2 clinical trials.