Sentences with phrase «allogeneic bmt»
In contrast, we found that VPA caused a slight decrease in the number of CD4 + Tregs in allogeneic BMT recipients.
http://www.jimmunol.org/
Because the long - term use of VPA in the clinical setting amassed pharmacokinetics and safety data, it is rational to test VPA in allogeneic BMT patients in combination with standard GVHD prophylaxis or treatment.
The infiltration of Th1 and Th17 cells into GVHD target organs (liver and lung), as well as the serum level of related cytokines, also were increased in allogeneic BMT recipients.
VPA was administered i.p. to allogeneic BMT recipients from day 0, with vehicle treatment as control.
To evaluate the impact of VPA treatment on the preservation of GVL activity, we challenged BALB / c recipients with host - type GFP + acute myeloid leukemia cells (H - 2d) to mimic residual leukemia in patients receiving allogeneic BMT.
«With this research from our longitudinal prospective assessment, we are able to deduce that a significant population of allogeneic BMT survivors will experience cognitive impairment that can and will impact different aspects of their lives moving forward,» Sharafeldin said.
«From this data, it's clear that we have to make strides in supporting allogeneic BMT recipients in their recovery to ensure that we are educating patients and their families on signs of cognitive impairment.
That's exciting because it provides strong evidence that this miR may be a good target for controlling cGVHD after allogeneic BMT.»
In the meantime, the MUSC team, led by Yu, will continue their work and try to extend the current findings by investigating how other miRs may be involved in regulating T - and B - cell function during allogeneic BMT.
Not exact matches
Allogeneic bone marrow transplant (BMT) is an essential treatment to cure patients with blood cancers such as leukemia.