Sentences with phrase «allogeneic responses»

There is evidence that MSC prevent normal allogeneic responses by directing CD4 + T cells to a suppressive or counter-regulatory phenotype 125, 126.

It implies that any residual engagement of the T cell receptor on Th cells would result in anergy and contribute to tolerance rather than allogeneic responses.

Thus MSC could prevent normal allogeneic responses either through modulation of DC function or by direct effects on T cells.

Not exact matches

In contrast, injections of the cells into immunologically unmatched recipients (called an allogeneic transplantation) caused the body to mount a stronger immune response.

There is supporting evidence for the use of allogeneic MSC from both in vitro and in vivo studies that show MSC avoid normal allo - responses.

Human mesenchymal stem cells modulate allogeneic immune cell responses.

These results suggest that MSC mediate allogeneic tolerance by directing APC towards a suppressor or inhibitory phenotype that results in an attenuated or regulatory T cell response.

Evidence from these studies indicates that the use of mismatched MSC does not provoke a proliferative T cell response in allogeneic MLR, thus suggesting an immunosuppressive role for MSC 83, 84, 85, 86, 87, 88.

CpG stimulation of precursor B lineage acute lymphoblastic leukemia induces a distinct change in costimulatory molecule expression and shifts allogeneic T cells towards a Th1 response.