Sentences with phrase «allograft transfer»
This may entail making small holes in the bone to allow new cartilage to grow (microfracture), taking cartilage from another part of the athlete's knee and transplanting it into the defect (osteochondral autograft transfer), taking cartilage cells from the knee and then having them grown in a lab for later re-implantation (autologous chondrocyte implantation), or taking cartilage from a person who has passed away and placing it in the defect (osteochondral allograft transfer).
https://sportstarsmag.com/ Not exact matches
Nude mice were challenged with BALB / c corneal allografts one day after the adoptive cell transfers.
An adoptive transfer experiment was performed to confirm that the high incidence of corneal allograft rejection was immune - mediated.
The results of a typical experiment are shown in Figure 3 and demonstrate that even though spleen cells from CD4 KO mice could adoptively transfer corneal allograft rejection, they did not display conventional CTL activity against either BALB / c corneal epithelial or endothelial cells.
Indeed, our results indicate that adoptive transfer of CD8 + T cells from CD4 KO mice that had rejected corneal allografts resulted in the rejection of 95 % of the corneal allografts transplanted to athymic recipients.
The capacity of CD8 + T cells to mediate corneal allograft rejection could have been due to the CTL population that might have been present in the CD8 + T cell suspensions used in the adoptive transfer inocula.
CD8 + and CD8 − T cells were collected from either C57BL / 6 mice or adoptive cell transfer recipients one week after the rejection of BALB / c corneal allografts.
Both CD8 − and CD8 + T cells from CD4 KO corneal allograft rejector mice mediated corneal allograft rejection following adoptive transfer to nude mice.
By contrast, adoptive transfer of CD8 − spleens cells from similar donors resulted in the rejection of corneal allografts in almost half of the hosts.
Additional adoptive transfer experiments were performed to ascertain the role of CD8 + and CD8 − T lymphocytes in CD4 - independent rejection of corneal allografts.
MSC - induced Tregs were donor - specific since adoptive transfer of splenocytes from tolerant mice prevented the rejection of fully MHC - mismatched donor - specific secondary allografts but not of third - party grafts.