Sentences with phrase «allografts showed»
In contrast, none of the syngeneic or rejected allografts showed any FoxP3 - expressing cells, as reflected by the merged stains of both FoxP3 and CD4 stains in F and G, respectively.
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The results of a typical experiment are shown in Figure 3 and demonstrate that even though spleen cells from CD4 KO mice could adoptively transfer corneal allograft rejection, they did not display conventional CTL activity against either BALB / c corneal epithelial or endothelial cells.
Histopathological examination of rejected corneal allografts in CD4 KO mice revealed a mixed inflammatory infiltrate containing large numbers of neutrophils and mononuclear cells, which was indistinguishable from the infiltrate seen in rejected corneal allografts in wild - type mice (data not shown).
Insufficient or excess complement activation has been shown to be important in a wide range of disease states, such as multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, rheumatoid arthritis, and age - related macular degeneration, as well as in allograft rejection.
Moreover, we have recently shown that interferon - γ (IFN - γ) KO mice, which can not mount classical Th1 immune responses, are nonetheless capable of rejecting corneal allografts (18, 19).
Interestingly, Azuma et al 167 showed that HGF treatment prevents chronic allograft nephropathy in rats.
Our data show, for the first time, the efficacy of ES - derived CD45 + HPCs to engraft in allogenic recipients without the use of immunosuppressive agents, there by protecting cardiac allografts from rejection.