Sentences with phrase «allografts which»

Not exact matches

The present demonstration of T cell - mediated apoptosis of allogeneic corneal cells from CD4 KO mice is consistent with previous findings, which noted the presence of apoptotic keratocytes and corneal endothelial cells in rejected corneal allografts in humans and rats respectively (5, 32).

The role of DN T cells in corneal allograft rejection was confirmed in two separate in vitro assays in which CD8 − cells were isolated from CD4 KO donors that had rejected corneal allografts and were found to induce apoptosis of donor - specific corneal cells.

Histopathological examination of rejected corneal allografts in CD4 KO mice revealed a mixed inflammatory infiltrate containing large numbers of neutrophils and mononuclear cells, which was indistinguishable from the infiltrate seen in rejected corneal allografts in wild - type mice (data not shown).

Moreover, we have recently shown that interferon - γ (IFN - γ) KO mice, which can not mount classical Th1 immune responses, are nonetheless capable of rejecting corneal allografts (18, 19).

However there are notable exceptions to these allorejection processes; the fetal allograft evades rejection by the mother through a complex series of actions, similarly tissue which has limited lymphatic drainage is less prone to allorejection 74, 75.

«The use of 15 - mg / kg ATLG was associated with statistically improved event - free survival in the subgroups of children with acute leukemia or with acute lymphoblastic leukemia, which represents the more frequent indication for an allograft in hematologic malignancies of childhood.»

In the tolerant allograft, FoxP3 + cells (C) and CD4 + (D) cells were detected, which overlapped when merged (E) suggesting that the CD4 + cells expressed FoxP3.

This preparation provides access to the patient's own stem cells, which may undergo osteogenic differentiation in response to delivery of the allograft BMDMSC.