Sentences with word «allopregnanolone»

Today, Maguire is on the scientific advisory board of Boston area — based Sage Therapeutics, which is testing a formulation of allopregnanolone called brexanolone.

Dr. Lee's research has shown that certain synthetic analogs of allopregnanolone with improved half - life can stimulate chloride uptake in synaptoneurosomes, protect against bicuculline - induced seizures in alcohol - dependent rats, and reduce alcohol intake in alcohol preferring rats.

Progesterone makes allopregnanolone in the brain, which interacts with GABA and serotonin for a foursome that truly soothes the female brain.

This is because the metabolite allopregnanolone, created in large amounts when progesterone is processed in the liver, stimulates GABA receptors in the brain, which promotes relaxation and helps balance the nervous system.

The caveat is that too high a dose of progesterone cream, or oral (pill) progesterone, can create byproducts such as allopregnanolone.

Although progesterone normally hits the GABA receptors in the brain and has anti-anxiety effects, progesterone can spill over into excess allopregnanolone and have a «paradoxical» effect in teens, causing increased sensitivity, anxiety, irritability and aggression.

Andreen, L., Sundstrom - Poromaa, I., Bixo, M., Andersson, A., Nyberg, S., and Backstrom, T. Relationship between allopregnanolone and negative mood in postmenopausal women taking sequential hormone replacement therapy with vaginal progesterone.

The higher levels suggest a system out of balance — the brain is making too much of one neurosteroid and not enough of another, called allopregnanolone, which is thought to protect against postpartum depression and is being tested as a treatment.

Gaba is in there too and allopregnanolone but I'm going to go with the threesome for now.

The best science shows that PMS is the result of the poorly synchronized dance between four entities: progesterone, allopregnanolone (a derivative of progesterone), and the GABA and serotonin pathways in the brain, which make you calm and happy.