Sentences with phrase «allosteric compounds»
Future studies will test and compare the efficacy of imatinib and allosteric compounds in mouse models of breast cancer.
http://stke.sciencemag.org/ Not exact matches
Fischetti and his colleagues chose to target the allosteric site of 2 - epimerase to develop inhibitory compounds, because it is found in other bacterial 2 - epimerases but not in the human equivalent of the enzyme.
In a departure from traditional drugs that «turn on» or «turn off» neurotransmitter receptors, Conn, Lindsley and their colleagues have developed compounds called «allosteric modulators» that can «tune» receptors like dimmer switches in an electrical circuit.
Together, our data suggest that clinical studies may be warranted to evaluate the therapeutic potential of ABL allosteric inhibitors and to determine whether combination therapies that incorporate these compounds are effective in treating metastatic breast cancer.
Vividion's Miralles says the techniques used to discover protein degraders also can be used to find compounds that target undruggable proteins through an allosteric effect or a protein - protein interaction.
The PI of the proposal has also experience in cheminformatics method development for chemical biology and therapeutic development (Mueller, R., et al.; «Discovery of 2 -(2 - Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound»; ChemMedChem; 2012; 7; 406).
The findings indicate that compounds known as positive allosteric modulators, or PAMS, can increase the natural pain - relief chemicals produced by the body in response to injury.