«It works as a huge
allosteric enzyme that allows one receptor to activate 35 kinases on the other side,» he says.
Another advance was the realization earlier by Gorfe in collaboration with J. Andrew McCammon of the University of California at San Diego and Barry Grant of the University of Michigan, as well as other scientists, that Ras is what's called
an allosteric enzyme.
Not exact matches
Fischetti and his colleagues chose to target the
allosteric site of 2 - epimerase to develop inhibitory compounds, because it is found in other bacterial 2 - epimerases but not in the human equivalent of the
enzyme.
Based on this work, the researchers identified a previously unknown regulatory mechanism in 2 - epimerase that involves direct interaction between one substrate molecule in the
enzyme's active site and another in the
enzyme's
allosteric site.
Furthermore, one important aspect about some alkaloids is that their tyrosinase inhibitory capacity might be attributed to the
allosteric effect on the
enzyme.
Researchers have long known about so - called
allosteric effects in
enzymes.
She worked on the
allosteric regulation of
enzymes, but the work didn't grab her.
In addition to the
enzymes that speeds up a reaction, other substances called
allosteric activators further increase the rate of reaction.