In the case of cancer, ineffective cell adhesion
allows tumour cells to detach and invade other tissues, thereby spreading cancer throughout the body.
This implies that cancer genes, and the mechanisms that
allow tumour cells to evade apoptosis, «have deep evolutionary roots».
Tumours spread with the help of enzymes called matrix metalloproteinases (MMPs), which destroy the connective tissue between cells and organs,
allowing tumour cells to break out of the original site and enter new ones.
Not exact matches
Tumours grow through a process of Darwinian evolution, where cancer
cells develop an advantageous mutation that
allows them to survive and multiply, producing a population of
cells which can mutate further.
«With this breakthrough it is possible to generate
cell models with the same alterations as observed in
tumour cells from patients, which will
allow us to study their role in
tumour development,» says CNIO researcher Sandra Rodríguez - Perales.
The new device will
allow for more accurate medical procedures that involve the use of ultrasound to kill
tumours, loosen blood clots and deliver drugs into targeted
cells.
This leads to the production of fatty acids — the building blocks of new
cells — thereby
allowing the
tumours to proliferate wildly.
This bank of living
tumour cells allowed the team to study not only the genetics of the
cells, but also how genetic mutations in the mitochondria — which drive energy production in the
cell — caused changes in the
cell's metabolism.
To identify procedures and safety systems that will
allow complete elimination of proliferative and / or
tumour - forming
cells from the graft
cell preparations;
Functional imaging using in vivo confocal microscopy which
allows the analysis of vaso - activity phenomena during hypoxia, of ischaemia reperfusion events, or of homing
cells in pathologic processes, such as
tumours or inflammatory diseases.
This
allows for potent
tumour cell killing, and an overall decreased metastatic burden.