However, when the researchers grew nerve cells that had no p75NTR in their observation chamber, they found that virus
transport along the axon is less frequent and much slower.
He uses a technique called diffusion spectrum imaging, which traces neural connections by following water molecules as they
diffuse along axons.
Co-author Jason Vevea, a UW - Madison postdoctoral fellow, produced videos showing tagged molecules of botulinum toxin
moving along the axons connecting neurons.
Co-author Jason Vevea, a UW — Madison postdoctoral fellow, produced videos showing tagged molecules of botulinum toxin moving
along the axons connecting neurons.
When the genomes «wake up,» new virus particles are made and these can
travel along the axon back out to the peripheral tissue, which creates the cold sores that can spread infection to new hosts.
This interrupts the transport of cellular materials along axonal microtubules, causing these materials to accumulate at several
points along the axon where they may give rise to varicosities.
DTI produces a measurement, called fractional anisotropy (FA), of the movement of water
molecules along axons.
When new signals fire
repeatedly along axons, the connections between the neurons strengthen, making them easier to fire in the same pattern in future.
This protein transport inside axons is carried out by motor proteins, molecular machines that much like our own legs, often
walk along axons in a bipedal manner carrying and delivering the proteins required for signaling to various regions along the length of axons.
VDACs are present in all neurons, especially the sodium and potassium
channels along the axons, which play a fundamental role in the generation of action potential and signaling between neurons.
Merck states: «The myelin sheaths of many nerve fibers promote transmission of the neural
impulse along the axon.
The researchers set up a system to grow asymmetric nerve cells in an observation chamber and use live cell imaging to track how rabies virus particles are
transported along the axons.
But a molecule of water is much more likely to
diffuse along an axon, for instance, than through the fatty myelin sheath encasing it.
For electrical signals to move between nerve cells, or from nerve cells to other cells (such as muscle cells), those signals must
travel along axons.
DTI «sees» the movement of water molecules within and
along axons, the nerve fibers that constitute the brain's white matter.