Sentences with phrase «along the genome»

There are an estimated 15 million places along our genomes where one base can differ from one person or population to the next.

The scientists had strategically inserted these foreign DNA «markers» at particular points along the genome, next to genes expressed only in embryonic stem cells.

Normally, they are held inactive by a series of marks along the genome.

All along, deCODE has churned out papers on genetic variants commonly involved in schizophrenia, diabetes, cancer, and other diseases, mostly by comparing markers scattered along the genomes of healthy and sick people.

We think that this simple explanation can account for the pattern of Neanderthal ancestry that we see today along the genome of modern humans.

Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different human cell types, including normal and cancerous colon, lung and liver cells, as well as brain, skin, blood and embryonic stem cells.

Epigenetic modifications, achieved along the genome by the chemical attachment of methyl molecules, or tags, to DNA, are reversible changes that alter which genes are turned on or off in a given cell without actually altering the DNA sequence of the cell.

In this month's issue of Genome Research, Elizabeth Stewart and her colleagues at Stanford University present this new map, which places about 8000 landmarks along the genome's 3 billion bases — DNA's building blocks — yielding twice the resolution of gene maps currently in use.

Researchers at the Okinawa Institute of Science and Technology Graduate University (OIST) have mapped the points along the genome where a scaffolding protein crucial to maintaining the genome's structure binds.

Patterns of genetic variation along the genome also revealed a total of 121 genes selected by Scythian breeders, most of which are involved in the development of forelimbs.

The group drew on known methylation signatures for various tissues to pick out methylated sites along the genome that provide unique fingerprints.

The team generated a profile of open and closed areas in eight stages of T - cell development and found an abundance of the transcription factor TCF - 1 at regions along the genome that were open at the earliest stages of development.

For the first time, these big data sets give us both a broad and exceptionally detailed picture of both biochemical activity along the genome and how DNA sequences have changed over time.»

Taylor and Ehrenreich, however, found that higher - order interactions of five or more places along the genome can have major impacts, and may help explain the so - called «missing heritability» problem, in which additive genetic variants do not entirely explain many inherited diseases and traits.

Instead, the project can start out by testing participants» DNA for so - called single nucleodtide polymorphism (SNPs), common mutations scattered along the genome that can point to disease risk genes.

In this subset, the team homed in on the number of differences at spots located close to one another along their genomes.

This allows us to determine the fractions of rightward -(R) and leftward -(L) moving forks at each locus, and to construct the complete profiles of replication fork directionality (RFD = R - L) along the genome.