Sentences with phrase «alpha cells in»

In those mice, but not in normal mice, they found that caerulein caused existing alpha cells in the pancreas to differentiate into insulin - producing beta cells.

Four years ago, the research team of Pedro Herrera (University of Geneva) first cast doubt on this assumption when they demonstrated that a few alpha cells in the pancreas of genetically modified diabetic mice changed into beta cells.

Not exact matches

A 2005 study published in the Journal of the American Dietetic Association found that almond consumption helped meet the Recommended Dietary Allowance of 15 mg / day alpha - tocopherol and improved red blood cell concentration.

And Rambo is top dog in the cell, ozil is putting his weight about well and is improving his reputation, Jack can be an alpha inmate but he will get bullied in the showers without the right men around him!

EGF, TGF - alpha, and human milk stimulate fetal small intestinal cell proliferation in vitro, with the greatest increase in cell proliferation seen following exposure to human milk.

In experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cellIn experiments with mice, the researchers found that Paneth cells engineered to lack a functional ATG16L1 gene were five times more likely to die in the face of rising TNF - alpha signals than normal cellin the face of rising TNF - alpha signals than normal cells.

Published in the Journal of Experimental Medicine online Oct. 31, the new study found that infliximab prevents TNF alpha from speeding the death of Paneth cells, which protect the gut from microbes.

The team tested whether overexpression of PGC1 - alpha could protect cultures of rat brain cells from the pesticide rotenone, which inhibits complex I of the electron transport chain in neuronal mitochondria and produces many symptoms similar to those of Parkinson's.

The data showed that when the cell phone was transmitting, the power of a characteristic brain - wave pattern called alpha waves in the person's brain was boosted significantly.

In addition, RNA that hybridizes with probes made from the clone is detected in wild - type S49 cells; however, cyc - S49 cells, which are deficient in Gs alpha activity, are devoid of this messenger RNIn addition, RNA that hybridizes with probes made from the clone is detected in wild - type S49 cells; however, cyc - S49 cells, which are deficient in Gs alpha activity, are devoid of this messenger RNin wild - type S49 cells; however, cyc - S49 cells, which are deficient in Gs alpha activity, are devoid of this messenger RNin Gs alpha activity, are devoid of this messenger RNA.

The researchers deployed this technology in yeast cells that are genetically engineered to overproduce a protein associated with Parkinson's disease, known as alpha - synuclein.

«Several major advances in recent years have been good news for multiple myeloma patients, but those new drugs only target terminally differentiated cancer cells and thus can only reduce the bulk of the tumor,» said Jamieson, who is also deputy director of the Sanford Stem Cell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego HeaCell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego HeaCell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego Heacell research at Moores Cancer Center at UC San Diego Health.

The increased alpha wave activity was greatest in brain tissue directly beneath to the cell phone, strengthening the case that the phone was responsible for the observed effect.

In contrast to the conversion of alpha cells, which only concerns a small fraction of the alpha cell population, the new mechanism involving delta cell fate change is a more efficient way of offsetting the loss of beta cells and thus diabetes recovery.

Cultures representing two other hereditary liver diseases, alpha 1 — antitrypsin deficiency (a protein - folding disorder that leads to cell death and liver failure) and glycogen storage disease, type 1a (in which a liver enzyme deficiency impairs the body's glucose metabolism), also displayed disorder - specific abnormalities.

Yet while alpha cells can reprogram into insulin production also in old mice, the ability of delta cells to do so is limited and does not extend beyond puberty.

With the engineered cells, researchers can screen new and existing drugs to see how they regulate alpha - synuclein level in patients.

The process of alpha cells converting to beta cells does not appear to have any age limitations — it occurred in young and old individuals — including some that had type 1 diabetes for decades.

Alpha cells and beta cells are both endocrine cells meaning they synthesize and secret hormones — and they exist right next to one another in the pancreas in structures called islets.

Whether in a yeast cell or in a neuron, alpha synuclein directly interfered with the rate of production of proteins in the cell, and the transport of proteins between cellular compartments.

The researchers replicated these three PKC alpha gene variants in laboratory cell lines.

«These findings underscore the significance of Gcn5 - regulated gene expression coupled with the metabolic enzyme alpha - KGDH in tumor cell proliferation and formation.»

«In our study, we demonstrated that alpha - KGDH, when coupled with Gcn5, induces histone succinylation and promotes tumor cell proliferation and tumor development.»

«We demonstrated that alpha - KGDH interacts with Gcn5 in the cell nucleus and found that tumor cell proliferation and tumor growth were inhibited when alpha - KGDH was blocked from entering the cell nucleus or by disruption of Gcn5's binding to succinyl - coenzyme A,» said Lu.

Then, in the early 1990s, scientists noticed that when they blasted cells with alpha particles, mutations cropped up even in cells that had not been directly hit.

The researchers found that Takinib inhibits an enzyme called TAK - 1, which serves as a switch controlling cell survival in the TNF - alpha signaling process.

Their study, which appears as a letter in the Sept. 8 edition of Nature Medicine, expands on work published in April showing that a combination of ribavirin and interferon - alpha 2b stops MERS - CoV from replicating in cell culture.

«Activation of these cell receptors appear to prevent brain cells from cleaning out the trash — the toxic buildup of proteins, such as alpha - synuclein, tau and amyloid, common in neurodegenerative diseases,» says the study's senior author, neurologist Charbel Moussa, MBBS, PhD, director of Georgetown's Laboratory for Dementia and Parkinsonism, and scientific and clinical research director of the GUMC Translational Neurotherapeutics Program.

In this study, we examined the effectiveness of a vaccination targeting tumors that produced IL - 15 and its cell surface receptor called IL - 15R - alpha -LRB--RRB- and examined their ability to up - regulate (or increase) immune responses to tumor antigens,» Morris says.

In the first, principal investigator Glass and colleagues investigated a pair of related transcriptional repressors called Rev - Erb - alpha and Rev - Erb - beta (proteins with important roles in regulating the circadian rhythm in many cell types) in mouse macrophageIn the first, principal investigator Glass and colleagues investigated a pair of related transcriptional repressors called Rev - Erb - alpha and Rev - Erb - beta (proteins with important roles in regulating the circadian rhythm in many cell types) in mouse macrophagein regulating the circadian rhythm in many cell types) in mouse macrophagein many cell types) in mouse macrophagein mouse macrophages.

Partial activation of the yeast pheromone response pathway by beta - adrenergic receptor agonists was achieved in cells coexpressing h beta - AR and a mammalian G protein (Gs) alpha subunit - demonstrating that these components can couple to each other and to downstream effectors when expressed in yeast.

Scientists from the Nencki Institute of Experimental Biology of the Polish Academy of Sciences in Warsaw have recently discovered that the alpha and beta cells communicate with each other, and the central role in this communication is played by cannabinoids — organic compounds that occur in nature also in inflorescences of cannabis.

«Under no circumstances should it be concluded from our work that consumption of marijuana can be a way to cure diabetes,» Prof. Dobrzyn warns and explains: «The concentration of glucose in the blood is determined by the balance between the activities of alpha and beta cells of the pancreas and insulin target tissues such as skeletal muscle and adipose tissue.

The insulin - producting beta - cells are in green and the glucagon - producting alpha - cells are in blue.

Alpha cells secrete glucagon hormone that increases glucose in blood, while the beta cells secrete insulin, the hormone decreasing glucose concentration.

Cannabinoids produced by the alpha cells may in fact activate cannabinoid CB1 receptors located in the pancreatic islets.

Croft believes the heightened alpha waves reflect the mind concentrating to overcome the electrical interference in brain circuits caused by the pulsed microwave radiation from cell phones.

The pathological hallmark of this disease is the accumulation of alpha - synuclein, which in turn leads to cell death and consequently to problems in neurotransmission.

Alpha - synuclein is the primary structural component of Lewy bodies, which are clumps of protein that develop inside nerve cells in Parkinson's disease and some other disorders.

Functional expression of the cDNAs in cultured mammalian cells generated receptors displaying alpha - amino -3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)- selective binding pharmacology (AMPA = quisqualate greater than glutamate greater than kainate) as well as cation channels gated by glutamate, AMPA, and kainate and blocked by 6,7 - dinitroquinoxaline -2,3-dione (CNQX).

Inside these cells is a protein called alpha - synuclein, which is known to go awry and lead to damaging clumps in the brains of Parkinson's patients, as well as those with Alzheimer's disease.

In the process they induce inflammation; the cells also secrete other inflammatory chemicals, like interleukin - 6 and tumor necrosis factor - alpha, which are known to adhere to the endothelium of the blood vessels, an early event in atherosclerosiIn the process they induce inflammation; the cells also secrete other inflammatory chemicals, like interleukin - 6 and tumor necrosis factor - alpha, which are known to adhere to the endothelium of the blood vessels, an early event in atherosclerosiin atherosclerosis.

In another set of experiments, the researchers found that fetal dendritic cells could block the production of TNF - alpha by adult T cells as well.

This causes the body's white blood cells to release type 1 interferon - alpha, a small cytokine protein that acts as a systemic alarm, triggering a cascade of additional immune activity as it binds with receptors in different tissues.

In Nrk mutant mammary glands, dense clusters of ER alpha - positive mammary epithelial cells were sometimes observed at late stages of pregnancy, which may represent the «bud» of the breast tumor.

The precise function of alpha - synuclein has been the subject of considerable debate, partly because it is abundant in red blood cells as well as in the brain.

As the name implies, Vα14 iNKT cells express a TCR with extremely limited diversity, consisting in mice of an invariant alpha chain (Vα14 - Jα18) generally paired with beta chains using Vβ8.2, 7 or 2.

They started with the experimental set up traditionally used for second harmonic generation studies in Geiger's group, which included a femtosecond laser oscillator from Newport Spectra Physics, optical lenses and mirrors, and a flow cell produced in - house for housing the alpha - quartz / water interface.

A panel of experts tackles the Alpha Stem Cell Clinic, a model introduced in the debut issue of STEM CELLS Translational Medicine, and the challenges in steering this concept around numerous hurdles as it moves from the bench to the bedside.

Han et al. demonstrated that in Caco2 cells, extracellular NAD + inhibited the binding of NF - kB to DNA by blocking the transcription of different genes involved in both inflammatory and aging pathways (interlukin - 6, interlukin - 1 beta, tumor necrosis factor alpha) 27.