Sentences with phrase «alpha cells into»

The researchers used an adeno - associated viral (AAV) vector to deliver to the mouse pancreas two proteins, Pdx1 and MafA, which reprogrammed plentiful alpha cells into functional, insulin - producing beta cells.

Not exact matches

Yet while alpha cells can reprogram into insulin production also in old mice, the ability of delta cells to do so is limited and does not extend beyond puberty.

Four years ago, the research team of Pedro Herrera (University of Geneva) first cast doubt on this assumption when they demonstrated that a few alpha cells in the pancreas of genetically modified diabetic mice changed into beta cells.

Building from two subunits, alpha and beta tubulin, this protein assembles into microtubules that play a vital role inside cells — giving structure, pushing or pulling other things around, or providing a track on which other molecules can pull themselves along.

In those mice, but not in normal mice, they found that caerulein caused existing alpha cells in the pancreas to differentiate into insulin - producing beta cells.

So our next step is to find out which molecule (s) caerulein is targeting on alpha cells that triggers their transformation into beta cells.

302 No 5651 pp 1772 - 1775 «Yeast Cells Provide Insights into Alpha - Synuclein Biology and Pathology» Authors: Tiago Fleming Outeiro and Susan Lindquist Whitehead Institute for Biomedical Research, Cambridge, MA

The alpha subunit of the heterotrimeric G - protein (Galpha) can then interact with intracellular partners and propagate the signal into the cell.

There are now multiple immunotherapies targeting clearance of alpha - synuclein from the brain in early - stage clinical trials, and multiple trials underway or in the works on the next generation of cell replacement therapies for dopaminergic neurons, including the TRANSEURO trial; the Summit4StemCell initiative, put together by Jeanne Loring — a researcher at The Scripps Research Institute who is exceptionally engaged with turning her research into therapies; a Japanese trial to be run by Jun Takahashi of Kyoto University in Japan (cf. here and here); and a trial centered at Memorial Sloan Kettering Cancer Center headed by cell biologist Lorenz Studer.

The pre-clinical study results show that the synthesized steroid, squalamine, prevents and eliminates alpha - synuclein build - up inside neurons by unsticking the protein from the inner wall of nerve cells, where it clings and clusters into toxic clumps, researchers say.

«Despite clear potential benefits for individuals with T1D, research into human alpha cell dysfunction within the context of T1D has been underappreciated and underfunded,» said Dr. Ben Williams, Program Officer of Helmsley's Type 1 Diabetes Program.

The new study found that T cells can be tricked into thinking dopamine neurons are foreign by the buildup of damaged alpha - synuclein proteins, a key feature of Parkinson's disease.

In contrast, the hormone glucagons is secreted into the bloodstream by pancreatic alpha cells upon sensing falling levels of blood glucose.

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Alpha - carotene, beta - carotene and beta - cryptoxanthin are carotenoids that the body converts into the form of vitamin A used by cells in the eyes that convert light into nerve impulses.