Sentences with phrase «alpha subunit»
The term "alpha subunit" refers to a part or component of a larger unit or molecule that holds a higher position or importance. It can be considered as a main or dominant part of a group or structure. Full definition
Palmitoylation at Cys - 416 is important for recruitment at both plasma membrane and lipid rafts and association with G protein alpha subunits.
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Heterotrimeric guanine nucleotide - binding regulatory proteins (G proteins) dissociate into guanosine triphosphate (GTP)- bound alpha subunits and a complex of beta and gamma subunits after interaction with receptors.
The GTP - alpha subunit complex activates appropriate effectors, such as adenylyl cyclase, retinal phosphodiesterase, phospholipase C, and ion channels.
Concentration - dependent inhibition of adenylyl cyclases by purified Gi alpha subunits is described.
Band - shift complementation assays show that U3A contains the E gamma subunit but does not contain an active E alpha subunit after treatment with IFN - alpha.
Canine chondrodysplasia in the Norwegian Elkhound and Karelian Bear Dog breeds is an autosomal recessive disease caused by a truncating mutation in collagen - binding Integrin Alpha Subunit 10 (CD - ITGA).
Associates with G protein alpha subunits, including G (i) alpha - 1 / GNAI1, G (i) alpha - 3 / GNAI3 and G (o) alpha / GNAO1; palmitoylation is important for interaction with GNAI3 and GNAO1 (PubMed: 27828947).
Control of yeast mating signal transduction by a mammalian beta 2 - adrenergic receptor and Gs alpha subunit
A complementary DNA clone encoding the alpha subunit of the adenylate cyclase stimulatory G protein (Gs) was isolated and identified.
The two inner rings consist of seven beta subunits each, and the two outer rings consist of seven alpha subunits each.
An antibody to a peptide synthesized according to deduced amino acid sequence reacts specifically with the alpha subunit of Gs.
The genes coding for the alpha subunit of T - cell receptors are on chromosome 14 and the gamma genes, whose function is yet to be determined, are on chromosome 13.
In the presence of Gs alpha, the alpha subunit of the G protein that activates adenylyl cyclase, one form of adenylyl cyclase was inhibited by beta gamma, some forms were activated by beta gamma, and some forms were not affected by beta gamma.
Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase
Next, the scientists plan to study what happens to the alpha subunit post-vibration and to unravel the cellular signaling leading to degranulation.
When the alpha subunit detaches from the beta subunit, the researchers suggest, the beta subunit produces signals inside mast cells that lead to degranulation, which causes hives and other allergy symptoms.
ADGRE2 is composed of two subunits — a beta subunit located within the cell's outer membrane, and an alpha subunit located on the outside surface of the cell.
After vibration, the alpha subunit of the mutant protein was no longer in close contact with the beta subunit.
Partial activation of the yeast pheromone response pathway by beta - adrenergic receptor agonists was achieved in cells coexpressing h beta - AR and a mammalian G protein (Gs) alpha subunit - demonstrating that these components can couple to each other and to downstream effectors when expressed in yeast.
(The two alpha subunits may bind either to the proNGF dimer before cleavage or to the complex of the gamma subunit and the NGF dimer after cleavage.)
But they also found it on another core protein called the beta subunit, suggesting the tail of the alpha subunit makes contact with the beta subunit as it plugs along.
No one knew if this tail — also known as the C - terminus of the alpha subunit — touches anything else in the core of the RNA polymerase complex.
The alpha subunit of the heterotrimeric G - protein (Galpha) can then interact with intracellular partners and propagate the signal into the cell.
Finally, the protein kinase PERK signals translational attenuation through phosphorylation of the alpha subunit of the eukaryotic translation initiation factor 2 (eIF2a) on serine residue 51.
SCNN1A (sodium channel, non-voltage-gated 1 alpha), also known as ENaCA (epithelial Na (+) channel subunit alpha) or amiloride - sensitive sodium channel subunit alpha, is the alpha subunit of the epithelial Na (+) channel (ENaC).
Interacts directly with G - protein alpha subunits and can functionally regulate their activity (By similarity).
The G - proteins come in different forms; the alpha subunit is covalently linked to myristic acid and the function of this subunit is important for turning on and off the binding to an enzyme called adenylate cyclase and thus the amplification of important hormone signals.
PRA in the Cardigan Welsh corgi, termed rod - cone dysplasia 3 (RCD3), is also caused by a mutation in a subunit of cGMP phosphodiesterase, this time the alpha subunit, which results in a disease with a comparable age of onset to RCD1 [4].