Sentences with phrase «alpha synuclein»

Propagation and aggregation of alpha synuclein in murine models S RAMBOZ WASHINGTON A, RAYNEL S, JASON B, NICOLE C, SHEILYN N, KIMBERLY C, KIM C, KENDALL W... Abstract / Posters

Once the researchers identified these genes in yeast, they tested the human equivalents in human neurons, grown in a lab dish, that also overproduce alpha synuclein.

Whether in a yeast cell or in a neuron, alpha synuclein directly interfered with the rate of production of proteins in the cell, and the transport of proteins between cellular compartments.

«The technical advances enabled high - resolution visualization of the formation of pathological alpha synuclein aggregates in hippocampal neurons.»

PsychoGenics has extensive experience working with both human and murine synthetic alpha synuclein fibrils in a variety of murine neurodegenerative disease models.

The researchers hypothesize that these chaperone proteins may assist in the proper folding of alpha synuclein, which could prevent it from forming clumps.

Earlier this year the company reported that patients who took PRX - 002 saw their alpha synuclein levels drop by as much as 96 %, which is a massive improvement that performed significantly better than a placebo.

Until now, scientists haven't thought this build - up was important to the disease process because it looked different from the types of protein accumulations — such as tau, amyloid and alpha synuclein — that are clearly toxic and always found in patients with Alzheimer's, Parkinson's and some forms of dementia.

Adding a tag called ubiquitin to the alpha synuclein prevents it sticking together into clumps (huntingtin does this too).