They found that
the alphavirus - based vaccine confers immunity to influenza comparable to a conventional DNA vaccine, but requires up to 1000-fold less DNA.
To minimize the amount of DNA in a flu vaccine, researchers at the Karolinska Institute in Stockholm, Sweden, turned to
an alphavirus called Semliki Forest Virus (SFV).
In test - tube experiments with hamster cells, the DNA vaccine created mRNA that both copied itself like it would in
the alphavirus and produced antigen.
Diamond's team found that a panel of cross-neutralizing monoclonal antibodies can potently inhibit both entry and release of more than one
alphavirus.