Sentences with phrase «already used in clinical trials»

A research team led by Gianluca Maddalo (KTH), involving several researchers at SciLifeLab, has discovered that melanoma resistance against BRAF and Hsp90 inhibitors can be overcome by implementing the current BRAF / MEK inhibitors therapy with a CDK2 inhibitor, dinaciclib, already used in clinical trials.

Not exact matches

Brendan Kennedy, the cofounder of Privateer Holdings, which owns various marijuana companies like Marley Natural and Canadian pharmaceutical - grade cannabis producer Tilray, explains how Tilray is already exporting marijuana to countries like Croatia and Australia for use in clinical trials.

AAV is in use in many late - stage clinical trials in the United States, and has already been approved for use in one gene therapy drug in the European Union.

Now a University of Colorado Cancer Center study published online ahead of print in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use of retinoic acid or other retinoids against some breast cancers: Because early clinical trials are often offered to patients who have already tried other more established therapies, breast cancer cells may have been pushed past an important tipping point that offers retinoic acid resistance.

The team is optimistic about CGP3466B because it has already been shown to be nontoxic and nonaddictive in phase I clinical trials that explored its use for Lou Gehrig's and Parkinson's diseases — though it did not prove effective in treating those conditions.

«Many of these methods are already being studied in clinical trials, but the path from clinical trials to routine clinical use is seldom easy,» Mankoff said.

And while their study was performed in mice, the drug used has already been tested in clinical trials to treat other, unrelated conditions.

Because the anti-retroviral drug maraviroc has already been approved by the U.S. Food and Drug Administration and has been shown safe for long term, oral use, it could be tested in clinical trials sooner rather than later, says Aleksander Popel, Ph.D., a professor in the Department of Biomedical Engineering at the Johns Hopkins University School of Medicine and member of the Johns Hopkins Kimmel Cancer Center.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

In clinical trials already underway, for example, researchers have used an older gene - editing technique, enzymes call zinc finger nucleases, in immune cells to deactivate the gene for CCR5, a surface protein that HIV latches onto in order to infect cellIn clinical trials already underway, for example, researchers have used an older gene - editing technique, enzymes call zinc finger nucleases, in immune cells to deactivate the gene for CCR5, a surface protein that HIV latches onto in order to infect cellin immune cells to deactivate the gene for CCR5, a surface protein that HIV latches onto in order to infect cellin order to infect cells.

«At Exeter we are already developing specific psychological therapies, running clinical trials of novel drug approaches and using - cutting edge genetic techniques to identify new targets for safe and effective therapies and to allow us to use current treatments in a more focussed way.»

Many of them have already been used in clinical trials.

This led the team to package the gene editing tool into AAV, used in late - phase clinical trials in the U.S. and also already approved in a gene therapy drug in the European Union.

As we'll see later on, this has already contributed to their receiving FDA - approval for use in a clinical trial.

He notes that AAV is already being used in gene therapy clinical trials for Parkinson's disease, hemophilia, and vision disorders.

The scientists say a clinical trial using salsalate to reduce tau levels in progressive supranuclear palsy, another tau - mediated neurological condition, has already been initiated.

They examined two inhibitors, one known as avibactam that is already being used in clinical trials, and another that is a bicyclic boronate inhibitor.

From the 128 drugs, 62 drugs are already under clinical trial against cancer, and two (Dasatinib and Vandetanib) are currently used in practice according to our literature survey.

The FDA currently has a loophole (officially known as the 510 (k) regulatory pathway) in place that allows manufacturers like DePuy to skip clinical trials if they can show that the new device is «substantially equivalent» to similar devices already in use.