Not exact matches
Next, Anderson and his colleagues used a set of genetic tools to
identify exactly which
neurons were responsible for the effect on aggression and to see if the gene that encodes for Tk
also controls aggressive behavior by acting in that cell.
The team were
also able to
identify the
neurons that reacted to the pheromones and kept the flies awake, showing a causal link between sexual arousal and sleep.
The researchers
also identified the specific
neuron responsible for detecting high pH. They did this by showing that when a specific sensing
neuron, called the ASH
neuron, was destroyed by laser microsurgery, the worms no longer avoided high pH. Going another step further, the researchers
also identified some of the proteins involved in the response to high alkalinity, which make up a calcium channel.
They
also applied it to human brain tissue collected by the Genotype - Tissue Expression (GTEx) Project, finding that they could a)
identify expression signatures unique to
neurons, glial cells, and other cell types in the brain (including rare types), and b) differentiate between closely related cell subtypes.
With simultaneous anatomical stainings they
also identified which of these
neurons sent their projections to the more remote secondary somatosensory area and the motor cortex, respectively.
Octopamine,
identified radioenzymatically in crude extracts, probably is
also localized in a few
neurons.
«We not only
identified the taste
neurons but
also found three receptor proteins that are important in sensing calcium.
Columbia University Medical Center (CUMC) researchers have
identified a gene, called matrix metalloproteinase - 9 (MMP - 9), that appears to play a major role in motor
neuron degeneration in amyotrophic lateral sclerosis (ALS),
also known as Lou Gehrig's disease.
In the featured article published online on April 5 in
Neuron, the researchers
also conclude that potential treatments targeting the transport disruptions they
identified in Huntington's disease
neurons may
also work for other neurodegenerative diseases, such as ALS and forms of dementia.
Scientists have
identified the molecular mechanism that leads to the death of
neurons in amyotrophic lateral sclerosis (
also known as ALS or motor neurone disease) and a common form of frontotemporal dementia.
They found that apoE4
also impairs the development of new
neurons in the hippocampus and
identified drug treatments that could block these detrimental effects.
In a screen of nearly 200,000 compounds, Tardiff and collaborators
identified one chemical entity that not only reversed alpha - synuclein toxicity in yeast cells, but
also partially rescued
neurons in the model nematode C. elegans and in rat
neurons.
The researchers
also show in their study (online Sep. 12, 2013, in
Neuron) that they could restore proper neuronal growth by compensating for the errant molecular mechanisms they
identified.
With similar precision, Professor Bargmann has
also identified many of the intracellular signalling pathways in C. elegans that relay information from cell surface odorant receptors (G protein - coupled receptors) to the interior of each sensory
neuron.