Sentences with phrase «also led to cell death»

The inhibition of Rac1 also led to cell death in mouse lungs cultured in the lab.

Not exact matches

The results could provide insights into the Zika virus» recent emergence as a global health emergency, and also point to inhibitors of the protein p53 as potential leads for drugs that could protect brain cells from cell death.

There is also some evidence that repeated bouts of intense exercise on consecutive days can lead to white blood cell death or dysfunction.

Cultures representing two other hereditary liver diseases, alpha 1 — antitrypsin deficiency (a protein - folding disorder that leads to cell death and liver failure) and glycogen storage disease, type 1a (in which a liver enzyme deficiency impairs the body's glucose metabolism), also displayed disorder - specific abnormalities.

Inflammation also erodes telomeres, the «caps» at the ends of chromosomes that protect genes from degradation, which can lead to early cell death, premature aging and even cancer.

This gene is also involved in programmed cell death, leading to an increased permeability of the mitochondrial membrane.

Recently, many scientists came to suspect that a protein called NF - κB, a master regulator of infection and inflammation, was at work; in 1996, several groups had found that it also inhibited cell death, which can lead to tumor formation.To find out whether suspicions about NF - κB were well - founded, molecular biologist Michael Karin of the University of California, San Diego, and his colleagues turned to a mouse model of colitis.

The Cambodian strain also led to the death of a few brain cells, but perhaps not enough to cause microcephaly.

Also, research in other animal models, such as rodents, has shown anesthesia exposure early in life can lead to cell death in the brain and cognitive impairments.

These results collectively suggest that neural stem cells need MSI1 to generate enough neurons for normal brain size, but the presence of MSI1 also increases the vulnerability of these cells to Zika infection, leading to the death of the population which ultimately results in microcephaly.

Although HIV researchers knew that intracellular transmission of the virus is a 100 - to 1,000 - times more - efficient means of infection than exposure to free particles called virions, Greene and his colleagues have now shown that cell - to - cell transmission is also more likely to lead to CD4 + T cell death.

Adding to the complexity of this disease, people with T1D also have dysfunctional alpha cells that, during activities such as exercise, permit uncorrected and dangerously low glucose levels that can lead to unconsciousness or even death.

«Programmed cell death, or apoptosis, is very important, particularly in the hematopoietic (blood forming) system, where inhibition of cell death leads to leukemias,» says Whitehead Institute Founding Member Harvey Lodish, who is also a professor of biology and a professor of bioengineering at MIT.

Thus, this treatment can not only lead to a slowing down or stopping of metastasis, but also to cell death.

The same study also suggests that the nutrient could lead to cancer cell death, also called apoptosis.

Also, a 2012 study published on the Medical Journal 3 Biotech shows that the anti-cancer compounds in mushrooms play a crucial role as a reactive oxygen species inducer, mitotic kinase inhibitor, antimitotic, angiogenesis inhibitor, topoisomerase inhibitor all leading to apoptosis (cell death) and eventually checking cancer cell proliferation (4).

It also helped protect against oxidative damage that leads to brain cell death, and reduced injury to brain endothelial cells in mice with high - fat diets.

Ingestion can also cause anemia (low red blood cell count) and, in severe cases, the anemia may lead to internal organ damage, organ failure or even death.