Sentences with phrase «also models diseases»
Gage's lab also models diseases in the laboratory using human stem cells.
http://www.salk.edu/ Not exact matches
But aside from raising awareness and more than $ 20 million for amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, over the past month, the challenge also may be unleashing a new model for the $ 300 billion - a-year business of charitable giving.
Although the observational studies that underlie our models all adjusted for multiple confounders, including known risk factors for the disease outcomes of interest, risk factors for early breastfeeding cessation such as preterm birth, preeclampsia, and obesity are also risk factors for metabolic disease in later life.
Creating and maintaining a healthy lifestyle that you stick to beyond the birth will also make you a model of healthy living for your child, helping him / her to avoid obesity, diabetes, heart disease and other conditions for a lifetime.
These findings allowed researchers to create a chimera virus: a mouse virus with a human viral gene that can be used to test molecules that inhibit human LANA protein in an animal model of disease, treating not only human herpes virus infection but also its associated cancers.
Exposed to both air and fluid, the cells might also be used to model the lungs and test drugs for lung disease.
The researchers also showed that both types of spirochetes (syphilis's Treponema pallidum and Lyme disease's Borrelia burgdorferi) respond to changes in viscosity in a similar manner and can be explained by the same biophysical model.
They can also be used to create novel disease models from which new drugs and therapies can be developed.
With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»
«Social media data have been suggested as a way to track the spread of a disease in a population, but there is a problem that in an emerging outbreak people also use social media to express concern about the situation,» explains study team leader Sherry Towers of ASU's Simon A. Levin Mathematical, Computational and Modeling Sciences Center.
The research is also the first to demonstrate beneficial effects of UDCA on dopaminergic neurons, the nerve cells affected in Parkinson's disease, in a fly model of Parkinson's disease which carries the same genetic change as some patients with the condition.
They also note that Aedes mosquitoes also spread dengue and chikungunya, two other notorious tropical diseases, so the model effectively measures risks of all three diseases rather than any one of them alone.
Their mathematical model also predicted how the Disneyland outbreak helped push California back from the tipping point by making parents more afraid of the disease than the vaccine.
The research team also screened candidate drugs using a «disease - in - a-dish» model.
It could also provide a model approach against other insect - borne diseases.
«This mouse model also will be useful in studies to further investigate impact of the omega - 3 omega - 6 ratio in disease prevention and treatment.»
Flaherty, who studies conditions such as hypergraphia (an uncontrollable urge to write) and writer's block, also looks to disease models to explain the drive behind this mode of communication.
The researchers developed a model of Alzheimer's disease and were surprised to find that increased levels of a gene involved in the production of toxic proteins in the brain not only led to Alzheimer's - like symptoms, but also to the development of diabetic complications.
The new compounds also reversed two symptoms of the disease in a fruit fly model of DM1.
Stem cell models, derived from healthy or diseased cells, are also being developed for use in drug efficacy and toxicity testing.
He originated the Barker Hypothesis, also known as the Developmental Origins of Health and Disease model, linking fetal and early infant experiences to an individual's health status across the lifespan.
Researchers at RTI International will continue to further refine their model to incorporate other national health issues, such as obesity, and to also assess how positive interventions could alter the course of kidney disease in America.
The team also showed that they could recover muscle growth and function in mouse models of muscular dystrophy, a disease with a known gene mutation.
In order to test their hypothesis in a model that more closely mimicked human disease, the researchers also tested the two drugs side - by - side on slices of tumors removed from patients during radical prostatectomy.
«Our model system provides us with fascinating insights into these mechanisms, which are also of great interest in the context of neurodegenerative diseases.»
Eggan has also been itching to use cloning technology to create embryonic stem cells that could be used to model the development of various diseases, especially diabetes and ALS.
the National Institutes of Health being the biggest funder but in the case of the flu, the Centers for Disease Control also fund their own research and a little bit about that research, and other countries also have their own ways of funding things, typically government, and the researchers in their current model of working, they are not required to release their scientific data until they publish it.
The nanosponges also reduced disease severity in a live mouse model of necrotizing fasciitis.
«It has the potential to inform clinical practice and also guides us about the relevance of animal models of human disease and how we can reduce and refine their use.»
«Additionally, the genetically - engineered mouse model will allow us to test potential treatments aimed at correcting achlorhydria, not just for gastric NETS, but also for other diseases of the gastrointestinal system such as Barrett's esophagus (chronic inflammation of the lower part of the esophagus), or hiatus hernia,» says Dr Calvete.
«There's a lot of literature that points to chondrodystrophy in dogs as an exciting animal model for degenerative disc disease in people,» said Bannasch, who also holds the Maxine Adler Endowed Chair in Genetics.
Later, he found that the inhibition of this signaling route also protected Alzheimer's - model mice from behavioral impairments and pathological phenomena typical to the disease.
This research is all aimed at tissue repair strategies, but it also may provide new in vitro models for human disease.
He is also developing a robust and comprehensive panel of 3 - D cell culture models from patient - derived primary cells that can be used to characterize different disease phenotypes and investigate the chemo - response of cells to novel or known drugs.
What's more, reducing receptor levels also prevented memory impairments in a mouse model of Alzheimer's disease.
Taking this one step further, the researchers performed the same experiments in a mouse model of Alzheimer's disease to see if these astrocytic adenosine receptors were also involved in memory loss associated with the disease.
Tobin also uses zebrafish to study bacteria closely related to those that cause tuberculosis, and findings from this model have been applied to understanding human disease.
Previous studies from this group have shown that lowering tau levels reduces abnormal brain activity in models of Alzheimer's disease, but this is the first demonstration that tau reduction may also be beneficial in intractable genetic epilepsy.
«Computer modeling, also known as in silico modeling, of such a complex disease allows us to work toward potential treatments much more rapidly.»
«The model also suggests ongoing warming of global temperatures will likely influence the ecology and distribution of such medically important ticks, favoring more tick - borne diseases among people and pets.
The pig model of HD also more closely matches the symptoms of the human disease.
They hope that these achievements might also serve as a model for improving the management of other disease stages and settings.
While ADNI researchers use maps such as these to study the pattern and range of degeneration among groups of patients over time, this model could also be used to monitor the progress of the disease in a single patient.
The solution, however, isn't simply finding better mouse models; it also involves redefining diseases to include the physiological underpinnings that mice illuminate so well.
They also provide new information to determine when the mouse is an appropriate model to study human biology and disease, and may help to explain some of its limitations.
Knowing that Notch governs vessel permeability makes it a candidate for new drugs to treat cardiovascular diseases as well, and the team is also investigating the TMD as a potential therapeutic agent itself, as cell models that were exposed to leak - inducing inflammation displayed a dramatic reduction in leakage when they were engineered to express the TMD.
Scientists also tested the drug in a mouse model of muscular dystrophy, since prednisone is normally given for this disease.
However, the modelling work also offers some encouraging news: the airborne transmission of the disease from East African countries directly to South Asia is highly unlikely, with transmission events possible only on less than one day a year.
It's now possible to not only model disease using the cells, but also to compare iPSCs from humans to those of our closest living relatives --- great apes, with which we share a majority of genes --- for insight into what molecular and cellular features make us human.
Since many liver pathologies also show regional variation, this tool may also serve as a basis for models of liver disease.»