Sentences with phrase «alter genes involved»

McClellan and his colleagues found that the mutations were much more likely to alter genes involved in brain development.

Not exact matches

Its altered form moves to the nucleus, where it increases the activity of a gene involved in metastasis (The Journal of Clinical Investigation, DOI: 10.1172 / JCI40433).

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

They identified 24 previously unknown epigenetic changes that alter a woman's risk of breast cancer and can be passed down through generations without involving changes in the DNA sequence of genes.

The virus essentially acts like a «sponge», preventing MSI1 from working correctly and altering the expression of many genes involved in neuronal development.

The «epi - marks» that adjusted parental genes to resist excess testosterone, for example, may alter gene activation in areas of the child's brain involved in sexual attraction and preference.

Not only were levels of metabolic compounds different, but the expression of certain genes involved in metabolism was turned up, and the epigenome of the cells — molecular markers on DNA that change gene expression on a broader scale — was altered.

Of 134 genes studied by the research team, 70 caused heart defects in fruit flies, and several of the altered genes are involved in modifying the structure of histones.

However, this cellular intervention alters the normal expression of hypophosphorylated retinoblastoma (RB) protein needed for the expression of genes involved in cell functions [3] and, therefore, results in an abnormal cell.

Focusing on just these protein - producing genes allows scientists to zero in on mutations that alter key proteins involved in cancer growth.

He has been involved in the identification of genes altered to cause muscular dystrophy since his 1986 identification of dystrophin as the causative gene in Duchenne muscular dystrophy.

Although most adult leukemias involving MLL affect a different part of the gene, the breakpoints found in infant leukemias and secondary leukemias occur predominantly in the small region altered by the bioflavonoids.

As for sleep, the scientists found that a particular gene shared with humans and involved in wakefulness is altered in dolphins.

These features were related to a modified gene expression pattern in adult male testes, showing an altered gene expression in genes involved in DNA repair and apoptosis that was confirmed by TUNEL assay.

It has been shown that the induction of an altered phenotype by a maternal protein restriction diet during pregnancy involves changes in DNA methylation and histone modifications in specific genes, including the glucocorticoid receptor (GR)(33 % lower; P < 0.001) and PPAR?

There is also the possibility of a genetic cause involving the p53 gene and an Rb gene which normally act as tumor suppresser genes and for some reason are altered preventing their usual functioning.

Surprisingly, they did this without altering the expression of genes thought to be involved with the calcification process.