Tumor cells carry a unique set of mutations in its genome that
alter normal cell functions.
Not exact matches
However, this cellular intervention
alters the
normal expression of hypophosphorylated retinoblastoma (RB) protein needed for the expression of genes involved in
cell functions [3] and, therefore, results in an abnormal
cell.
However, using these
cell lines it should be possible to determine in detail how the defects arise (which is difficult in patients), and perhaps how to
alter the segregation of mutant versus
normal mtDNA during
cell division to eventually lessen the burden of abnormal mitochondria
function.
Her current research is focused on discovering how
normal and disease melanocyte
cell states establish distinct regulatory DNA landscapes, and also determining how the combination of both genetic variation within these regulatory regions and environmental
cell signals
alter gene expression and
normal cell function.
Unlike in type 1 diabetes, in which insulin production is limited because beta
cells are destroyed, «arsenic induces glucose intolerance through a disruption of beta -
cell function that
alters normal stimulus — secretion coupling,» the researchers wrote.
This sudden movement causes stretching and tearing of connections between brain
cells and creates chemical changes that
alter normal brain
function.