Sentences with phrase «alter protein expression»

Rare variations, by contrast, are more likely to alter protein expression or function and therefore have a direct or causal association with a disease.

Not exact matches

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

Those studied by Dunlop are her colleagues alter their traits — protein expression, for instance — but not their genomes, making them significantly more difficult to identify since the resistance level of each bacterium changes over time.

The expression levels of other enamel matrix proteins and enamel proteases, were not significantly altered, although the expression of an enamel protease, KLK - 4, was delayed.

«Margery's experiments showed that the NS1 protein can alter expression of Hedgehog target genes on its own, without other viral proteins,» said Bier, professor and newly named holder of the Tata Chancellor's Endowed Professorship in Cell and Developmental Biology.

mTOR controls expression of proteins that alter mitochondrial structure and function in ways that unexpectedly protect cells from death, the team reported.

«We have shown that the synthesis of nitric oxide (NO), known to regulate gut motility functions and NRF2, a transcriptional factor known to regulate several antioxidant genes, mediated Phase II protein expression have been altered in colon specimens of polybacterialinfected ApoE - / - mice,» said Miriam Walker.

In their new paper, Shi and colleagues report that reactivation of cocaine memories in rats alters the expression of a protein that releases lactate from glia and enables nerve cells to take up lactate.

However, the team was able to show that so - called tight junction proteins, which are known to be important for the blood - brain barrier permeability, did undergo structural changes and had altered levels of expression in the absence of bacteria.

DNA methylation and other epigenetic alterations — chemical changes to DNA that can alter a gene's expression without affecting its protein - coding sequence — may underlie some of the lasting biochemical havoc, Ghanei says.

Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a gene called LMNA, which encodes a protein called prelamin A. Progeria patients experience a buildup of an abnormal version of prelamin A in their cells that, among other changes, distorts the nucleus and alters gene expression.

These datasets will allow the characterization of how genetically different parasites that cause distinct types of human toxoplasmosis alter the expression of protein - encoding and miRNA - encoding genes in both the human host and the parasite.

Dr. Rossi has shown that with the expression of RAD52, a protein not usually expressed in HDR, and dn53BP1, an altered form of 53PB1 (regularly found in the NHEJ pathway), he was able to enable efficient HDR at multiple points of the genome in patient - derived induced pluripotent stem cells.

I am currently exploring functions of BIN1 by generating mouse models to modify the levels of BIN1 expression in the brain, and investigating how altering the levels of this protein can modify AD - related pathophysiology.

However, this cellular intervention alters the normal expression of hypophosphorylated retinoblastoma (RB) protein needed for the expression of genes involved in cell functions [3] and, therefore, results in an abnormal cell.

It will have secondary and further effects, altering mechanisms and rates of gene expression for other proteins, and thus may or may not end up achieving the result that theory suggests it will.

Enterohemorrhagic E. coli alters murine intestinal epithelial tight junction protein expression and barrier function in a Shiga toxin independent manner.

In vivo expression of G - protein β1γ2 dimer in adult mouse skeletal muscle alters L - type calcium current and excitation - contraction coupling

Rather than modify protein structure and function, these noncoding variants frequently impact regulatory elements and thereby alter the quantitative and spatiotemporal regulation of gene expression.

Survival motor neuron protein deficiency impairs myotube formation by altering myogenic gene expression and focal adhesion dynamics.

High - throughput ChIP - Seq: One of the major questions for researchers interested in understanding chromatin dynamics is to investigate how protein - DNA interactions alter Epigenetic profiles and subsequent gene expression.

Our biological studies suggest that a critically reduced amount of this protein alters cell shape, migration, proliferation, and gene expression to the detriment of brain, heart, and kidney development.

One potential explanation for a reduced inflammatory response is that regular yoga practice may alter gene expression and protein synthesis.

The protein, ATF4, is a transcription factor that alters gene expression in skeletal muscle, causing reduction of muscle protein synthesis, strength, and mass.