Sentences with phrase «alter protein sequence»

The most common approach is to focus on protein - truncating variants or PTVs (sometimes also called loss - of - function variants *) that terminate or substantially alter the protein sequence.

«The fact that the genetic code can simultaneously write two kinds of information means that many DNA changes that appear to alter protein sequences may actually cause disease by disrupting gene control programs or even both mechanisms simultaneously,» said Stamatoyannopoulos.

Only 3 of 66 confirmed de novo mutations (3.6 %) altered protein sequence.

On average, the authors 1,140 somatic mutations, including 154 that altered protein sequence, and 12 somatic structural rearrangements.

The researchers also found evidence of extensive RNA editing, which allows the octopus to alter protein sequences without changing underlying DNA code.

Not exact matches

The larger scale Cancer Genome Atlas study provided the information needed to alter proteins or RNA sequences that may act as «drivers» for prognostic biomarkers or therapeutic targets.

Its competitors — designer proteins called zinc finger nucleases and TALENs — also precisely alter chosen DNA sequences, and several companies are already exploiting them for therapeutic purposes in clinical trials.

To prove that the UL6 protein sequence does in fact trigger the autoimmune attack of HSK, Cantor and his team have now infected mice with either normal HSV - 1 or a strain that they had genetically altered to lack the UL6 protein.

DNA methylation and other epigenetic alterations — chemical changes to DNA that can alter a gene's expression without affecting its protein - coding sequence — may underlie some of the lasting biochemical havoc, Ghanei says.

Synonymous single - nucleotide polymorphisms (SNPs) do not produce altered coding sequences, and therefore they are not expected to change the function of the protein in which they occur.

But the protein can also change the genetic sequence of a normal cell, altering the body's blueprint and making mutations that cause cancers.

Although the human and chimpanzee genomes are distinguished by 35 million differences in individual DNA «letters,» only about 50,000 of those differences alter the sequences of proteins.

Since the methylation of cytosine does not alter the DNA sequence, but only influences when and where these proteins are produced, it is considered an epigenetic modification.

Zoghbi's lab also found that this altered ATXN1 gene sequence encodes a bulky, improperly folded protein that is toxic to brain cells.

Protein - altering variants within 500 kb of 22 «index SNPs» uncovered in targeted sequencing of GWAS loci

A significant proportion of SVs affect known protein - coding genes by altering coding sequence or gene dose.

We used high - throughput sequencing in families with multiple cases of IBD, followed by genotyping of cases and controls, to investigate whether rare protein altering genetic variants are associated with susceptibility to IBD.

We estimate that 42 % of our cohort carry pathogenic DNMs in coding sequences; approximately half of these DNMs disrupt gene function and the remainder result in altered protein function.