Sentences with phrase «alter synaptic»

Changes in the abundance of these receptors alter synaptic transmission in the aged brain.

Long - term BACE1 inhibition in the neurodevelopmental stage caused the loss of synaptic proteins but failed to alter synaptic proteins in the already developed maintenance stage.

We also conduct electrophysiological, biochemical, imaging, antd behavioral studies with various knockout and transgenic mice to determine how precise genetic manipulations that either activate or abolish specific translational control mechanisms alter synaptic function and behavior.

Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability.

He also studies how dysregulated translational control contributes to altered synaptic function and aberrant behaviors in developmental brain disorders and neurodegenerative disease.

When soy lecithin supplements were given throughout perinatal development, they reduced activity in the cerebral cortex and «altered synaptic characteristics in a manner consistent with disturbances in neural function.»

Both achieve their effects by altering the synaptic organization of the brain.

Maternal care and hippocampal plasticity: evidence for experience - dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress.

One final example is the prefrontal cortex, which is thought to play an important role in regulating behavior by suppressing impulses and emotions arising from the amygdala and other parts of the limbic system.50 — 52 In animal studies, exposure to chronic stress or glucocorticoids alters the synaptic connectivity within the prefrontal cortex, 52,53 and this may limit the ability of the prefrontal cortex to (1) suppress the impulsivity and aggression of the limbic system, and (2) execute adaptive responses (rather than maladaptive responses) to stress.54 — 56 Stress - induced changes in brain structure parallel the well - described impact of significant childhood adversity on a variety of brain functions, including the modulation of physiologic responses (hyper - responsive or chronically active stress response), learning (impaired memory), and the regulation of behavior (the ability to execute adaptive vs maladaptive responses to stress).3, 39,57

Not exact matches

Synaptic plasticity, the ability of neurons to alter the strength of their synaptic connections with activity and experience, is thought to play a critical role in memory Synaptic plasticity, the ability of neurons to alter the strength of their synaptic connections with activity and experience, is thought to play a critical role in memory synaptic connections with activity and experience, is thought to play a critical role in memory storage.

The synaptic responses to two consecutive stimuli were also altered.

«This opens the door to follow the natural evolution of synaptic density with normal aging and follow how drugs can alter synapses or synapse formation.»

Instead, the molecular processes triggered by memory formation and recall could reflect the stabilization of previously altered or recently retrieved synaptic connections.

With the combined use of genetics and pharmacology, the investigators altered the production of proteins controlled by eIF2α in adult mice, essentially converting them into adolescents by making them more susceptible to cocaine - induced changes in synaptic strength and behavior.

A Gain - of - Function Mutation in the α9 Nicotinic Acetylcholine Receptor Alters Medial Olivocochlear Efferent Short - Term Synaptic Plasticity

We also study how molecular signaling, translational control, synaptic plasticity, and behavior are altered in mouse models of developmental disability, autism, aging, and Alzheimer's disease.

Archaerhodopsin Selectively and Reversibly Silences Synaptic Transmission through Altered pH. Cell Reports, 16 (8), 2259 - 2268.

Advances in optical imaging and optogenetics combined with electrophysiological recordings enable Albeanu and colleagues to monitor and / or alter patterns of activity at unprecedented synaptic and millisecond resolution, in real time, as animals are engaged in various behaviors.

Altered representation of the spatial code for odors after olfactory classical conditioning: memory trace formation by synaptic recruitment.

Over-expression of stargazin leads to increases of extra-synaptic AMPA receptors whilst over-expression of PSD95 leads to increased recruitment of synaptic receptors, but in neither case is synaptic function altered (Schnell et al 2002).

Notably, we have found that prolonged activation of these pathways results in altered translational control, which contributes to synaptic dysfunction and memory deficits in AD model mice.

Our main aim is to study synaptic function under physiological conditions and to investigate how the factors contributing to normal signalling are altered in disease, identifying new therapeutic strategies.

In addition to fragile X syndrome, my laboratory also has conducted studies to determine whether the signaling cascades that normally are required for long - lasting synaptic plasticity and memory are altered in mouse models of several developmental disorders, iincluding autism spectrum disorder (ASD), intellectual disability (ID), tuberous sclerosis complex (TSC), and Angelman syndrome.

''... we hypothesize that repeated stress - related allostatic overload may affect brain function at three basic levels: (a) at the cellular level, it may compromise proteostasis (e.g. tau protein), organelles homeostasis, and induce epigenetic changes in neuronal DNA; (b) at the tissue level it may affect intracellular communication (synaptic contacts), number of cells (reduction of neuronal density), composition of the extracellular matrix (accumulation of amyloid plaques), and neuroinflammation; (c) at the systemic levels it may alter the brain's regulation of behavior (cognitive decline).

Growth of the synaptic web is utterly different from concrete physical things which maintain cells» metabolism and alters their structural and functional energetic state.

Neonatal isolation stress alters bidirectional long - term synaptic plasticity in amygdalo - hippocampal synapses in freely behaving adult rats